Results 41 to 50 of about 315,445 (219)

Family structure influences the gut microbiota of the Sino-Mongolian beaver (Castor fiber birulai) rather than age and genderNCBI Sequence Read Archive (SRA)

Global Ecology and Conservation
Gut microbiota is crucial for the health and survival of wildlife. In this study, metagenomic analysis was performed on fecal samples of endangered Sino-Mongolian beavers (Castor fiber birulai) from three groups rescued in the wild, to explore the ...
Wenwen Chu, Zhichao Zhou, Xiaoyun Li, Chi Ma, Yuting Gao, Wenpu Huang, Fangyi Liu, Dong Zhang, Kai Li   +8 more
doaj   +1 more source

Comparative Analysis of Gut Microbiota Changes in Père David's Deer Populations in Beijing Milu Park and Shishou, Hubei Province in China

Frontiers in Microbiology, 2018
This study used 16S rRNA high-throughput sequencing technology to examine the differences in gut microbiota between the Père David's deer populations in the Beijing and Shishou areas of China in order to understand the effects of ex situ conservation on ...
Meishan Zhang, Minghui Shi, Mengyuan Fan, Shanghua Xu, Yimeng Li, Tianxiang Zhang, Muha Cha, Yang Liu, Xiaobing Guo, Qi Chen, Yiping Li, Shumiao Zhang, Defu Hu, Shuqiang Liu   +13 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evidence for dilution effect by Gobio gobio, a dead-end host in the Unio crassus–Cyprinidae coevolutionary system

Scientific Reports
Freshwater mussels (Unionidae) depend on specific fish hosts to complete their life cycle. Glochidia, their parasitic larvae, must attach to the gills or fins of suitable fish species to metamorphose.
Jacek Dołęga, Tadeusz A. Zając, Adam Ćmiel, Anna Lipińska, Krzysztof Tatoj, Katarzyna Zając   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies

BMC Genomics, 2019
Background Under caged conditions, birds are affected more severely by environmental stressors such as dietary structure, activity space, human disturbances, and pathogens, which may be reflected in the gene expression in peripheral blood or other ...
Yu Wang, Jinxin Guo, Lin Wang, Hengjiu Tian, Jinling Sui   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Body measurements of mountain reedbuck Redunca fulvorufula fulvorufula from Rolfontein Nature Reserve, South Africa

Koedoe: African Protected Area Conservation and Science, 1993
Morphometric data of 92 adult mountain reedbuck are presented. Males were significantly heavier than females, and the tails of the males were significantly longer than those of the females.
M.D. Andersen, J.H. Koen
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source