Results 51 to 60 of about 181,914,409 (290)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Teaching and Learning Science in the 21st Century: Challenging Critical Assumptions in Post-Secondary Science

open access: yesEducation Sciences, 2018
It is widely agreed upon that the goal of science education is building a scientifically literate society. Although there are a range of definitions for science literacy, most involve an ability to problem solve, make evidence-based decisions, and ...
Amanda L. Glaze
doaj   +1 more source

Modeling Instruction and the Nature of Science [PDF]

open access: yes, 2005
Thesis chair, Dr. Virginia Epps. This file was last viewed in Adobe Reader 7.0High school students hold naïve conceptions about the nature of science (NOS),believing that scientific knowledge is absolute, that science is an objective activity without ...
Fishwild, Jon E.
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Penerapan Pembelajaran Sains Berbasis Inquiry Based Learning Terintegrasi Nature of Science Terhadap Literasi Sains

open access: yesJurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2020
: The aim of research was to describe the effect of the application of Inquiry-Based Learning (IBL) integrated the Nature of Science (NOS) on student scientific literacy.
Utaria Mutasam   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Examining science teacher’s understandings of the NOS aspects through the use of knowledge test and open-ended questions [PDF]

open access: yesScience Education International, 2010
The nature of science aspects (NOS) are the most emphasized theme inmany curriculum and reform attempts. Teachers as a curriculumimplementer in the classroom play important role for policy, arrangementsand classroom experiences on NOS understandings of ...
Jale Cakiroglu, Mustafa Serdar Koksal
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Pemahaman Nature of Science (NoS) Di Era Digital: Perspektif Dari Mahasiswa PGSD

open access: yesJIPI (Jurnal IPA dan Pembelajaran IPA), 2019
Hakikat IPA merupakan cara berpikir seseorang dalam memahami konsep-konsep ilmiah melalui metode ilmiah dengan berbagai tahapan dan metodologi yang sistematis sehingga dapat menghasilkan temuan atau ilmu pengetahuan, oleh sebab itu pentingnya pemahaman ...
Tursinawati Tursinawati, Ari Widodo
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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