Results 41 to 50 of about 183,335 (218)

Left-shifted Nav channels in injured bilayer: primary targets for neuroprotective Nav antagonists?

Frontiers in Pharmacology, 2012
In sodium channel (Nav)-rich axon initial segments and nodes of Ranvier, mechanical, ischemic and inflammatory injuries render these voltage-gated channels dangerously leaky.
Catherine E Morris, Pierre Alexandre Boucher, Bela eJoos   +2 more
doaj   +1 more source

Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels

Biomolecules, 2020
Voltage-gated sodium (Nav) channels drive the rising phase of the action potential, essential for electrical signalling in nerves and muscles. The Nav channel α-subunit contains the ion-selective pore. In the cardiomyocyte, Nav1.5 is the main Nav channel
Samantha C. Salvage, Christopher L.-H. Huang, Antony P. Jackson   +2 more
doaj   +1 more source

Glial βii spectrin contributes to paranode formation and maintenance [PDF]

, 2018
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous ...
Benusa, Savannah D., Chang, Kae Jiun, Dupree, Jeffrey L., Galiano, Mauricio Raul, Griggs, Ryan B., Huang, Claire Yu Mei, Liu, Yanhong, Rasband, Matthew N., Susuki, Keiichiro, Tsai, Chang Ru, Yermakov, Leonid M., Zhang, Chuansheng, Zollinger, Daniel R.   +12 more
core   +1 more source

Revisiting paravertebral muscles in European rabbits (Oryctolagus cuniculus) and European brown hares (Lepus europaeus) (Leporidae; Lagomorpha)

The Anatomical Record, EarlyView.
Abstract Domesticated European rabbits (Oryctolagus cuniculus) have long been chosen as laboratory model organisms. Despite this, there has been no definitive study of the vertebral musculature of wild rabbits. Relevant descriptions of well‐studied veterinary model mammals (such as dogs) are generally applicable, but not appropriate for a species ...
Nuttakorn Taewcharoen, Emma Sherratt, Philip Stott, Rachel Norris   +3 more
wiley   +1 more source

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels

Marine Drugs, 2014
Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound ...
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat   +8 more
doaj   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Enacting shared narratives in work counselling

Nordvei
Work counselling is complex and challenging. Research highlights the importance of user involvement and client-professional relationships for successful counselling outcomes.
Marie Sorgendal, Nina Petersen Reed
doaj   +1 more source

Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT MRI of the heart and abdominal organs provides unparalleled soft tissue contrast and quantitative biomarkers, yet remains highly susceptible to physiological motion. Contractions of the myocardium, respiratory excursions, peristalsis, vascular pulsatility, and unpredictable bulk patient movement generate artifacts that impair image quality ...
Eric M. Schrauben, Gastao Lima da Cruz, Christopher W. Roy, Thomas Küstner   +3 more
wiley   +1 more source

Pricing Efficiency of Exchange Traded Funds in India

Organizations and Markets in Emerging Economies, 2020
Exchange traded funds (ETFs) have two prices, the market price and the net asset value (NAV) price. ETFs NAV price gets determined by the net value of the constituent assets, whereas the market price of ETFs depends upon the number of units bought or ...
Y V Reddy, Pinkesh Dhabolkar
doaj   +1 more source

Comparable clinical outcomes in functionally aligned computer‐assisted and image‐based robotic assisted total knee arthroplasty

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To determine the clinical outcomes differences and complications in two comparable groups of patients undergoing computer aided surgery (CAS) and robotic‐assisted (RA) posterior stabilised (PS) total knee arthroplasty (TKA) following functional alignment (FA) principles with tibial pre‐cut at a minimum of 4‐year follow‐up. Methods This
Stefano Seracchioli, Francesco Zambianchi, Sebastiano Clemenza, Mattia Clò, Riccardo Cuoghi Costantini, Fabio Catani   +5 more
wiley   +1 more source