Results 61 to 70 of about 40,568 (249)

Assessment of verbal comprehension and non-verbal reasoning when standard response mode is challenging: A comparison of different response modes and an exploration of their clinical usefulness

Cogent Psychology, 2017
Objective: Assessment of cognition is important for providing children with developmentally appropriate interventions. Often children with severe speech and motor disorders are not assessed, as standardized assessment is perceived as challenging.
Ramune Kurmanaviciute, Kristine Stadskleiv   +1 more
doaj   +1 more source

Hvorfor lykkes ikke NAV-kontorene med å jobbe mer arbeidsrettet?

Søkelys på Arbeidslivet, 2016
Sammendrag En sentral forklaring på NAVs manglende måloppnåelse om flere i arbeid og aktivitet og færre på trygd har vært omstillingsprosessen med den lokale etableringen av NAV-kontorene.
Knut Fossestøl, Eric Breit, Elin Borg
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Szakmai gyakorlatom a NAV-nál

, 2015
A záró dolgozatom témája a Nemzeti Adó – és Vámhivatal. A 12 hetes szakmai gyakorlatomat a Nemzeti Adó – és Vámhivatal Észak-alföldi Regionális Adó Főigazgatóságán töltöttem a Törvényességi és Felülellenőrzési Osztályon illetve a Jogi és Koordinációs ...
Szabó, Izabella
core  

Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

eLife, 2020
Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer, Marko A Popovic, Xante Wilders, Sara Grasman, Oriol Pavón Arocas, Maarten HP Kole   +5 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Final report on SET-Nav policy briefs

, 2019
1. Introduction 2. Innovation Systems and the SET – Plan 2.1 Systemic Perspective on Energy Innovation 2.2 Research on Innovation Systems and the SET Plan 2.3 Policy Recommendations and the SET Plan 3.
Herbst, Andrea, Wilson, Charlie, Olmos, Luis, Heitel, Stephanie, Selei, Adrienn, Rehfeldt, Matthias, Sensfuss, Frank, Fleiter, Tobias, Köhler, Jonathan, Kranzl, Lukas, Ansari, Dawud, Holz, Franziska, Forthuber, Sebastian, KIM, Yeong Jae, Aichinger, Eric, Perez-Valdes, Gerardo A., Egging, Ruud, Karakosta, Charikleia, Müller, Andreas, Boitier, Baptiste, Lumbreras, Sara, Pedro Crespo del Granado, Krail, Michael, Welisch, Marijke, Papapostolou, Katerina, Resch, Gustav, Toth, Borbala, Johansen, Ulf, Fougeyrollas, Arnaud, Hartner, Michael, Ramos, Andrés, Coningsby, Louis, Bernath, Gerda Deac Christiane, Kotek, Peter   +33 more
core  

Veratridine-Induced Oscillations in Nav 1.7 but Not Nav 1.5 Sodium Channels Are Revealed by Membrane Potential Sensitive Dye

Membranes
Voltage-gated sodium channels (Navs) are critical for membrane potential depolarisation in cells, with especially important roles in neuronal and cardiomyocyte membranes.
Sarah C. R. Lummis, Samantha C. Salvage, Christopher L.-H. Huang, Antony P. Jackson   +3 more
doaj   +1 more source

FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons

eLife, 2014
Rapid firing of cerebellar Purkinje neurons is facilitated in part by a voltage-gated Na+ (NaV) ‘resurgent’ current, which allows renewed Na+ influx during membrane repolarization.
Haidun Yan, Juan L Pablo, Chaojian Wang, Geoffrey S Pitt   +3 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source