Results 71 to 80 of about 194,089 (280)

Brevetoxin versus Brevenal Modulation of Human Nav1 Channels

Marine Drugs, 2023
Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to and activates voltage-gated sodium (Nav) channels in native tissues, whereas brevenal antagonizes these actions.
Rocio K. Finol-Urdaneta, Boris S. Zhorov, Daniel G. Baden, David J. Adams   +3 more
doaj   +1 more source

Crystal structures of Ca2+–calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Calmodulin (CaM) is a Ca2+-sensing protein that endows several voltage-gated sodium (NaV) and calcium (CaV) channels with Ca2+-dependent inactivation (CDI).
B. Gardill, Ricardo E. Rivera-Acevedo, Ching‐Chieh Tung, F. van Petegem   +3 more
semanticscholar   +1 more source

Nav channels in cancers: Non-classical roles

, 2020
Background: Primary adenoid cystic carcinoma (ACC) is the second most common primary tracheal neoplasms but the data for optimal treatment plan is limited.
Hengrui Liu
semanticscholar   +1 more source

Spatiotemporal Fire Patterns and Post‐fire Forest Change in Peru (2000–2021)

Land Degradation &Development, EarlyView.
ABSTRACT Fire is increasingly more frequent and severe in many tropical regions, leading to significant forest loss, diminished biodiversity, and reduced Nature's contributions to people (NCPs). In this study, we analyzed the spatiotemporal patterns of fire in Peru and its regions, focusing on: (1) burned area, (2) size, and (3) number of fires, using ...
Maricel Móstiga, Dolors Armenteras, Jordi Vayreda, Javier Retana   +3 more
wiley   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Place-train i møte med aktiveringspolitikk og tverrsektoriell samhandling: En litteraturbasert drøfting av norsk praksis

Søkelys på Arbeidslivet
Et utviklingstrekk i arbeidsmarkedspolitikken både i Norge og internasjonalt er økt bruk av inkluderingsinnsatser som foregår på ordinære arbeidsplasser (place-train) og mindre bruk av tiltak som skal forberede den enkelte på å møte arbeidslivets krav ...
Line Fossum Skogstad
doaj   +1 more source

Study protocol for a randomized controlled trial of the effectiveness of adding motivational interviewing or stratified vocational advice intervention to usual case management on return to work for people with musculoskeletal disorders. The MI-NAV study

BMC Musculoskeletal Disorders, 2020
Background Little research exists on the effectiveness of motivational interviewing (MI) on return to work (RTW) in workers on long term sick leave.
B. Øiestad, Fiona Aanesen, I. Løchting, K. Storheim, Alexander Tingulstad, T. Rysstad, M. Småstuen, A. Tveter, G. Sowden, G. Wynne-Jones, E. Fors, M. V. van Tulder, R. Berg, N. Foster, M. Grotle   +14 more
semanticscholar   +1 more source

Simulation-based model course to demonstrate seafarers' competence for deck officers' discipline [PDF]

, 2014
Postprint (published ...
Barahona Fuentes, Claudia, Boran-Keshishyan, A., Castells Sanabra, Marcel·la, Cross, Stephen, Hofman, Wibbo, Kondratiev, A., Moncunill Marimon, Jorge, Muyskens, Cees, Ordás Jiménez, Santiago, Popov, A., Skorokhodov, S.   +10 more
core  

A Component-Based Simplex Architecture for High-Assurance Cyber-Physical Systems

, 2017
We present Component-Based Simplex Architecture (CBSA), a new framework for assuring the runtime safety of component-based cyber-physical systems (CPSs).
Clark, Matthew, Grosu, Radu, Phan, Dung, Schierman, John D., Smolka, Scott A., Stoller, Scott D., Yang, Junxing   +6 more
core   +2 more sources

Missense Variants in the A Isoform of FGF13 as a Novel Cause of Paroxysmal Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Pathogenic variants within the unique N‐terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X‐linked dominant epileptic encephalopathy (DEE). Objective The aim was to expand the clinical and molecular spectrum of FGF13A‐related disorder.
Cyril Mignot, Matthildi Athina Papathanasiou Terzi, Claudia Ravelli, Elisabeth Bosch, Xueqin Lin, Adeline Trauffler, Roseline Caumes, Andrew E. Fry, Clementine Fort, Gaelle Gauthe, Regina Trollmann, Thomas Wirth, Mathieu Anheim, Aurélie Méneret, Emmanuel Roze, Jean‐Madeleine de Sainte Agathe, Hailan He, Eleni Panagiotakaki, Gaëtan Lesca, André Reis, Diane Doummar, Thomas Smol, Georgia Vasileiou   +22 more
wiley   +1 more source