Results 41 to 50 of about 1,995,126 (241)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Subtree isomorphism is in random NC
Discrete Applied Mathematics, 1990 A subtree isomorphism problem is to determine for given two trees G and H whether there is a subgraph (subtree) of H that is isomorphic to G. Unlike other versions of the (sub)graph isomorphism problem this one is known to be in P, yet the existence of a fast parallel algorithm to solve it posses an interesting problem.
Phillip B. Gibbons +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Recent Developments In Bronchial Thermoplasty For Severe Asthma
Journal of Asthma and Allergy, 2019 Neil C Thomson Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UKCorrespondence: Neil C ThomsonInstitute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow G12 OYN, UKTel +44-141-211-1673Email ...
Thomson NC
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A new CNC programming method using STEP-NC protocol [PDF]
FME Transactions, 2017 A new programming method of CNC Machine tools, which is developing as an alternative to G code, is AP238 protocol or STEP-NC, according to ISO 10303 standard.
Živanović Saša T., Vasilić Goran V.
doaj
Clinical Ophthalmology, 2021 Natacha C Villegas, Wen-Shin Lee Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USACorrespondence: Natacha C VillegasDepartment of Ophthalmology, Stanford University, Medical Center, 2452 Watson Court, Palo Alto, CA ...
Villegas NC, Lee WS
doaj
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Journal of Pain Research, 2018 Nicholas C ConnollyBend Anesthesiology Group, Bend, OR, USAMultimodal approaches are recommended to achieve effective postsurgical analgesia with reduced opioid reliance and are integral to enhanced recovery after surgery (ERAS) protocols.
Connolly NC
doaj
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source