Results 51 to 60 of about 1,995,126 (241)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Evaluation of the implementation of a patient portal pilot intervention among people with type 2 diabetes at community health centers

Frontiers in Clinical Diabetes and Healthcare
IntroductionA pilot study of a multilevel, 6-month intervention (MAP) designed to increase patient portal use among patients with type 2 diabetes at community health centers (CHCs) showed promising results.
Julie Wagner, Samuel Akyirem, Joanna Lipson, Helen NC Chen, Helen NC Chen, Helen NC Chen, Robin Whittemore   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Finite difference schemes with monotone operators

Advances in Difference Equations, 2004
Several existence theorems are given for some second-order difference equations associated with maximal monotone operators in Hilbert spaces. Boundary conditions of monotone type are attached.
Apreutesei NC
doaj  

'NC-Sunshine' and 'NC-Stratford' Slicing Cucumber Hybrids [PDF]

HortScience, 2005
Four slicing (fresh-market) cucumber inbreds (NC-58, NC-59, NC-62, and NC-63) and two hybrids (‘NC-Stratford’ and ‘NCSunshine’), were developed at North Carolina State University. As with most cucumber cultivars released from N.C. State, ‘NC-Stratford’ and ‘NC-Sunshine’ were named for places around the state. ‘NC-Stratford’ is the F 1 of NC-58 × NC-59,
openaire   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

'NC-Davie' and 'NC-Duplin' Pickling Cucumber Hybrids [PDF]

HortScience, 2005
Four pickling (processing) cucumber inbreds (NC-54, NC-55, NC-56, and NC-57) and two pickling cucumber hybrids (‘NCDavie’ and ‘NC-Duplin’), were developed at North Carolina State University. As with most cucumber cultivars released from N.C. State, ‘NC-Davie’ and ‘NC-Duplin’ were named for places around the state. ‘NC-Davie’ is the F 1 of NC-54 × NC-55,
openaire   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Multicomponent mass transfer kinetics in nanocomposite (NC) bifunctional matrixes: NC selectivity and diffusion concentration waves

Nanotechnology Reviews, 2014
In this review, the author’s results are observed in the field of the computerized modeling of the multicomponent mass transport kinetic processes in the bifunctional matrixes of the various shapes: spherical r-bead, cylindrical ro-fiber, planar L ...
Kalinitchev Anatoliy
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source