Results 1 to 10 of about 149,617 (194)
Stem Cell Research, 2021 NGLY1 deficiency is a rare recessive genetic disease caused by mutations in the NGLY1 gene which codes for N-glycanase 1 (NGLY1). Here, we report the generation of two gene corrected iPSC lines using a patient-derived iPSC line (NCATS-CL6103) that ...
Ivan Pavlinov +11 more
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Identifying androgen receptor antagonists using a metabolically competent high-throughput screening assay [PDF]
Current Research in ToxicologyAndrogen receptor (AR) is a nuclear receptor with a well-established role in sexual function and development. Modifications in AR can lead to endocrine disruption, cancer, and other diseases, making it imperative to identify compounds that influence ...
Caitlin Lynch +5 more
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JMIR Mental Health, 2021 BackgroundMild traumatic brain injury (mTBI) occurs at a higher frequency among military personnel than among civilians. A common symptom of mTBIs is cognitive dysfunction.
Jones, Chelsea +5 more
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Scientific Reports, 2021 The recent global pandemic of the Coronavirus disease 2019 (COVID-19) caused by the new coronavirus SARS-CoV-2 presents an urgent need for the development of new therapeutic candidates.
Hu Zhu +9 more
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Frontiers in Pharmacology, 2023 Efficiently circumventing the blood-brain barrier (BBB) poses a major hurdle in the development of drugs that target the central nervous system. Although there are several methods to determine BBB permeability of small molecules, the Parallel Artificial ...
Rintaro Kato +10 more
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DEIA is essential to advance the goals of translational science: Perspectives from NCATS
Journal of Clinical and Translational Science, 2023 The National Center for Advancing Translational Science (NCATS) seeks to improve upon the translational process to advance research and treatment across all diseases and conditions and bring these interventions to all who need them. Addressing the racial/
Shadab F. Hussain +16 more
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Gene Therapy: The View from NCATS [PDF]
Human Gene Therapy, 2016 The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) was established in December 2011. NCATS mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of interventions that improve human health across a wide range of ...
Brooks, Philip J. +2 more
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NCATS Inxight Drugs: a comprehensive and curated portal for translational research [PDF]
Nucleic Acids Research, 2021 Abstract The United States has a complex regulatory scheme for marketing drugs. Understanding drug regulatory status is a daunting task that requires integrating data from many sources from the United States Food and Drug Administration (FDA), US government publications, and other processes related to drug development.
Vishal B Siramshetty +10 more
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Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]
, 2018 NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B. +94 more
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Influence of White Etching Bands Formation on Integrity of Rolling Element Bearings
Tribology Online, 2023 The development of subsurface microstructural alterations known as dark etching regions (DERs) and white etching bands (WEBs) in rolling element bearings due to rolling contact fatigue have been investigated for the past eight decades, focusing on their ...
Mostafa El Laithy +3 more
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