Results 31 to 40 of about 149,617 (194)

A review of the validity of computerized neurocognitive assessment tools in mild traumatic brain injury assessment

Concussion, 2017
Computerized neurocognitive assessment tools (NCATs) offer potential advantages over traditional neuropsychological tests in postconcussion assessments. However, their psychometric properties and clinical utility are still questionable.
Jacques P Arrieux, Wesley R Cole, Angelica P Ahrens   +2 more
doaj   +1 more source

Enhancement of Neuroglial Extracellular Matrix Formation and Physiological Activity of Dopaminergic Neural Cocultures by Macromolecular Crowding

Cells, 2022
The neuroglial extracellular matrix (ECM) provides critical support and physiological cues for the proper growth, differentiation, and function of neuronal cells in the brain.
Andy N. Vo, Srikanya Kundu, Caroline Strong, Olive Jung, Emily Lee, Min Jae Song, Molly E. Boutin, Michael Raghunath, Marc Ferrer   +8 more
doaj   +1 more source

Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X-linked protoporphyria. [PDF]

, 2019
BackgroundErythropoietic protoporphyria (EPP) and X-linked Protoporphyria (XLP) are rare photodermatoses presenting with severe phototoxicity. Although anecdotally, providers who treat EPP patients acknowledge their life-altering effects, tools that ...
Anderson, Karl E, Balwani, Manisha, Bissell, D Montgomery, Bloomer, Joseph, Bonkovsky, Herbert L, Desnick, Robert J, Naik, Hetanshi, Overbey, Jessica R, Phillips, John D, Singal, Ashwani, Wang, Bruce   +10 more
core   +1 more source

Searching for a Needle in a Haystack: Cas9-Targeted Nanopore Sequencing and DNA Methylation Profiling of Full-Length Glutenin Genes in a Big Cereal Genome

Plants, 2021
Sequencing and epigenetic profiling of target genes in plants are important tasks with various applications ranging from marker design for plant breeding to the study of gene expression regulation.
Ilya Kirov, Ekaterina Polkhovskaya, Maxim Dudnikov, Pavel Merkulov, Anastasia Vlasova, Gennady Karlov, Alexander Soloviev   +6 more
doaj   +1 more source

Barriers and facilitators to HPV vaccination in primary care practices: A mixed methods study using the Consolidated Framework for Implementation Research [PDF]

, 2018
Background In the United States, the effective, safe huma papilloma virus (HPV) vaccine is underused and opportunities to prevent cancer continue to be missed.
Dodd, Sherry, Garbutt, Jane M, Kulka, Katharine, Lee, Amanda A, Lobb, Rebecca, Walling, Emily   +5 more
core   +2 more sources

PMP22 exon 4 deletion causes ER retention of PMP22 and a gain-of-function allele in CMT1E [PDF]

, 2017
OBJECTIVE: To determine whether predicted fork stalling and template switching (FoSTeS) during mitosis deletes exon 4 in peripheral myelin protein 22 KD (PMP22) and causes gain‐of‐function mutation associated with peripheral neuropathy in a family with ...
Bai, Yunhong, Connolly, Anne M, Grider, Tiffany, Kamholz, John, Lupski, James R, Shy, Michael E, Wang, David S, Wu, Xingyao, Zaidman, Craig   +8 more
core   +2 more sources

NCATS–Industry Project Gains Backers [PDF]

Cancer Discovery, 2012
Abstract An effort by the National Institutes of Health's National Center for Advancing Translational Sciences to connect academic researchers with industry to revive drugs that passed safety testing but failed for their initial treatment indications has signed on 5 additional pharmaceutical companies.
openaire   +1 more source

349 Rare Disease Alert System (RDAS) to promote rare disease research

Journal of Clinical and Translational Science
Objectives/Goals: Rare disease patients often face lengthy delays in receiving accurate diagnoses or experience misdiagnoses due to a lack of available information.
Timothy Sheils, Devon Leadman, Jaber Valinejad, Minghui Ao, Shixue Sun, Sungrim Moon, Yanji Xu, Qian Zhu   +7 more
doaj   +1 more source

Experiments with LDA and Top2Vec for embedded topic discovery on social media data—A case study of cystic fibrosis

Frontiers in Artificial Intelligence, 2022
Social media has become an important resource for discussing, sharing, and seeking information pertinent to rare diseases by patients and their families, given the low prevalence in the extraordinarily sparse populations.
Bradley Karas, Sue Qu, Yanji Xu, Qian Zhu   +3 more
doaj   +1 more source

509 Regulatory Lens of a QA/QC Project Manager

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: The primary purpose of the QA/QC Project Manager (PM), appointed under the NCATS UL1 administrative supplement award, is to facilitate quality and timely NCATS prior approval submissions preventing study start delays.
Rachel Bennett, Christine Sego Caldwell
doaj   +1 more source