Results 41 to 50 of about 149,617 (194)

I-Corps@NCATS trains clinical and translational science teams to accelerate translation of research innovations into practice

Journal of Clinical and Translational Science, 2021
Introduction: A key barrier to translation of biomedical research discoveries is a lack of understanding among scientists regarding the complexity and process of implementation.
Kathryn Nearing, Julie Rainwater, Stacey Neves, Pamela Bhatti, Bruce Conway, Nathaniel Hafer, Kevin Harter, Nicholas Kenyon, Margaret M. McManus, Demetria M. McNeal, Elaine H. Morrato, Suhrud M. Rajguru, Molly Wasko   +12 more
doaj   +1 more source

Micromechanical model of bovine Haversian bone predicts strain amplification through soft interfaces [PDF]

, 2013
Context. Recent observations of brown dwarf spectroscopic variability in the infrared infer the presence of patchy cloud cover. Aims. This paper proposes a mechanism for producing inhomogeneous cloud coverage due to the depletion of cloud particles ...
Nobakhti, Sabah, Katsamenis, Orestis, Andriotis, O., Limbert, Georges, Thurner, Philipp J.   +4 more
core   +4 more sources

Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma

Orphanet Journal of Rare Diseases, 2023
Background Glioblastoma (GBM) is the most aggressive and common malignant primary brain tumor; however, treatment remains a significant challenge.
Erin McGowan, Jaleal Sanjak, Ewy A. Mathé, Qian Zhu   +3 more
doaj   +1 more source

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Frontiers in Pharmacology, 2022
Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various ...
Md Kabir, Md Kabir, Elias C. Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez, Eric Gonzalez, Lin Ye, Xin Hu, Mark J. Henderson, Menghang Xia, Xin Xu   +12 more
doaj   +1 more source

NCATS Is Out of the Bag [PDF]

Cancer Discovery, 2012
Abstract NIH has officially launched the National Center for Advancing Translational Sciences, a “hub for catalyzing innovations in translational science.”
openaire   +1 more source

Building capacity for collaborative research on opioid and other substance use disorders through the Clinical and Translational Science Award Program

Journal of Clinical and Translational Science, 2020
The opioid crisis in the USA requires immediate action through clinical and translational research. Already built network infrastructure through funding by the National Institute on Drug Abuse (NIDA) and National Center for Advancing Translational ...
Linda B. Cottler, Alan I. Green, Harold Alan Pincus, Scott McIntosh, Jennifer L. Humensky, Kathleen Brady   +5 more
doaj   +1 more source

Unbiased image segmentation assessment toolkit for quantitative differentiation of state-of-the-art algorithms and pipelines

BMC Bioinformatics, 2023
Background Image segmentation pipelines are commonly used in microscopy to identify cellular compartments like nucleus and cytoplasm, but there are few standards for comparing segmentation accuracy across pipelines.
Vishakha Goyal, Nick J. Schaub, Ty C. Voss, Nathan A. Hotaling   +3 more
doaj   +1 more source

Terfenadine resensitizes doxorubicin activity in drug-resistant ovarian cancer cells via an inhibition of CaMKII/CREB1 mediated ABCB1 expression

Frontiers in Oncology, 2022
Ovarian cancer is one of the most lethal gynecological malignancies. Recurrence or acquired chemoresistance is the leading cause of ovarian cancer therapy failure.
Wei Huang, Wei Huang, Shu Yang, Yu-Shan Cheng, Ni Sima, Wei Sun, Min Shen, John C. Braisted, Weiguo Lu, Weiguo Lu, Wei Zheng   +10 more
doaj   +1 more source

Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury [PDF]

, 2020
The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction.
Bagiella, Emilia, Christoforou, Andrea, Giacino, Joseph T., Hammond, Flora M., Long, David, Maurer-Karattup, Petra, Sherer, Mark   +6 more
core   +1 more source

Financing translation: Analysis of the NCATS rare-diseases portfolio

Science Translational Medicine, 2015
Simulations using National Center for Advancing Translational Sciences data show that a portfolio of rare-disease therapeutics can yield attractive financial returns.
Fagnan, David E., Yang, N. Nora, McKew, John C., Lo, Andrew W   +3 more
openaire   +5 more sources