Results 71 to 80 of about 20,747 (199)

Characterization of the canine CLCN3 gene and evaluation as candidate for late-onset NCL

BMC Genetics, 2006
Background The neuronal ceroid lipofuscinoses (NCL) are a heterogenous group of inherited progressive neurodegenerative diseases in different mammalian species. Tibetan Terrier and Polish Owczarek Nizinny (PON) dogs show rare late-onset NCL variants with
Distl Ottmar, Wohlke Anne, Drogemuller Cord   +2 more
doaj   +1 more source

Introduction to the constraint language NCL

The Journal of Logic Programming, 2000
The design, implementation and application of a natural constraint language NCLare presented. At the solver level, to support the solving of a large scope of combinatorial problems, a rich set of conventional constraints is defined within a constraint framework that strongly combines Boolean logic, integer constraints and set reasoning over finite ...
openaire   +3 more sources

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Site‐specifically modified α‐synuclein containing DOPA or phosphorylation was prepared by ligation of a bacterially expressed N‐terminal polypeptide and a synthetic C‐terminal modified peptide. ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease.
Tatsuhito Matsuo, Isao Suetake, Mariko Kimura, Satoshi Hashimoto, Koichi Matsuo, Sakiko Matsumoto, Shinji Hirotsune, Hironobu Hojo   +7 more
wiley   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, Volume 183, Issue 17, Page 5355-5371, September 2026.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, Volume 249, Issue 3, Page 565-577, September 2026.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Ludovic Mousseron, Despoina Chousianiti, Francis Poulat, Bérangère Legois, Reiner A. Veitia, Anne‐Laure Todeschini   +5 more
wiley   +1 more source

Overexpression of Nucleolin is a Potential Prognostic Marker in Endometrial Carcinoma

Cancer Management and Research, 2021
Qianhan Lin,1,2,* Xiaoxue Ma,1,2,* Shunxue Hu,3 Rui Li,1,2 Xuan Wei,1,2 Bing Han,1 Yanhui Ma,1 Peishu Liu,1,2,4 Yingxin Pang1,2,4 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People’s ...
Lin Q, Ma X, Hu S, Li R, Wei X, Han B, Ma Y, Liu P, Pang Y   +8 more
doaj  

Synthesis of β‐Thiolated Amino Acids: Investigation Toward the Total Chemical Synthesis of Lasso Peptide Microcin J25

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Lasso peptide, Microcin J25 (MccJ25), exhibits extreme stability and potent antibacterial activity against Gram‐negative bacteria due to its rigid “lariat” structure. However, this unique topology precludes researchers to achieve the total chemical synthesis. Herein, we investigated the chemical synthetic prestapling strategy toward synthesis of MccJ25
Yu‐Ting Hsiao, Bethan L. Heard, Ilia Perov, Marco J. van Belkum, Sorina Chiorean, Kaitlyn Towle, Isaac Antwi, John C. Vederas   +7 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Post‐Translational Isoaspartate Promotes Amyloid Formation in β2‐Microglobulin

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Chemical synthesis of five β2‐microglobulin (β2m) variants reveals the structural impact of Asn deamidation. By introducing Asp or isoAsp at susceptible Asn‐Gly sequences, we demonstrate that isoAsp17 formation specifically accelerates amyloid fibril formation, highlighting its potential contribution to dialysis‐related amyloidosis.
Ryuji Kawakami, Toshiki Takei, Masatomo So, Toshifumi Takao, Yoshinori Taguchi, Hironobu Hojo   +5 more
wiley   +2 more sources