Results 51 to 60 of about 35,363 (287)
Recent Insights into NCL Protein Function Using the Model Organism Dictyostelium discoideum
Cells, 2019 The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating neurological disorders that have a global distribution and affect people of all ages.
Meagan D. McLaren +2 more
semanticscholar +1 more source
For staff on the frontline: How are you? [PDF]
, 2020 Nurses are working at the frontline of this current crisis providing the acute and critical care that is needed to Covid-19 patients (and when present their relatives), attending to the mental health of service users deeply affected by the inherent ...
Shaw, Claire
core +3 more sources
Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease
Cell Communication and Signaling, 2021 Neurodegenerative diseases like Alzheimer’s, Parkinson’s and Huntington’s disease involves abnormal aggregation and accumulation of toxic proteins aggregates. Post-translational modifications (PTMs) of the causative proteins play an important role in the
Abhishek Ankur Balmik +1 more
doaj +1 more source
Advancement of scienceRecent studies suggest that circular RNA (circRNA)‐mediated post‐translational modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis of hepatocellular carcinoma (HCC).
Xin Hu +18 more
semanticscholar +1 more source
Cardiac pathology in neuronal ceroid lipofuscinoses (NCL): More than a mere co-morbidity.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2019 The neuronal ceroid lipofuscinoses (NCLs) are mostly seen as diseases affecting the central nervous system, but there is accumulating evidence that they have co-morbidities outside the brain.
K. Rietdorf +5 more
semanticscholar +1 more source
NCL-WT and 6/S*A interact with endogenous NCL.
, 2014 Nuclear extracts (NE) were prepared from cells grown without Dx for at least 10 d for NCL-WT or 6/S*A expression. Ctrl represents control cells without exogenous NCL expression.
Xin Li (51274) +8 more
core +1 more source
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Oncogenesis, 2022 As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intracellular calcium homeostasis implicated in the occurrence of multiple types of diseases.
Chunming Gu +9 more
doaj +1 more source
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8. [PDF]
Brain PatholWe describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Lindgren U +5 more
europepmc +2 more sources
NCL-INSPECTOR. UMA FERRAMENTA PARA INSPEÇÃO DE APLICAÇÕES NCL
, 2010 Ginga-NCL e a linguagem NCL foram recomendadas como ambiente de multimídia interativo e linguagem para IPTV, pela União Internacional das Telecomunicações (ITU do Inglês: International Telecommunication Union).
GUSTAVO DE SA CARVALHO HONORATO
core +1 more source