Results 61 to 70 of about 35,363 (287)

Nucleolin (NCL) inhibits the growth of peste des petits ruminants virus

Journal of General Virology, 2019
Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that is caused by peste des petits ruminants virus (PPRV). To date, the molecular mechanism of PPRV infection is still unclear.
Dandan Dong, Shiqian Zhu, Qiuhong Miao, Jie Zhu, Ao-Xing Tang, Ruibin Qi, Teng Liu, Dong-Dong Yin, Guang-Qing Liu   +8 more
semanticscholar   +1 more source

Study on Influencing Factors Analysis of Gastric Tube Insertion Length and Construction of Estimation Method

Frontiers in Surgery, 2022
BackgroundInfluenced by individual differences, the depth of gastric tube placement is often different. Clinically, it is necessary to seek a simple and accurate gastric tube insertion scheme to improve the clinical efficacy of indwelling gastric tube ...
Hua Zhang, Huaqin Wang, Huaqin Wang, Xiaoyu Fan, Xiangqun Cao, Wan Su, Bo Yang   +6 more
doaj   +1 more source

Ncl Synchronously Regulates Na+, K+, and Cl− in Soybean and Greatly Increases the Grain Yield in Saline Field Conditions

Scientific Reports, 2016
Salt stress inhibits soybean growth and reduces gain yield. Genetic improvement of salt tolerance is essential for sustainable soybean production in saline areas. In this study, we isolated a gene (Ncl) that could synchronously regulate the transport and
T. Do, Hua-Tao Chen, H. T. Vu, A. Hamwieh, Tetsuya Yamada, Tadashi Sato, Yong-Liang Yan, H. Cong, M. Shono, K. Suenaga, Dong-He Xu   +10 more
semanticscholar   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Repression of Virulence in Staphylococcus aureus by 2-Aminothiol-Mediated Quorum Quenching. [PDF]

Angew Chem Int Ed Engl
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Gless BH, Milazzo R, Bojer MS, Sereika-Bejder BS, Ingmer H, Olsen CA.   +5 more
europepmc   +3 more sources

One dimensional normal consolidation line equation

Journal of the Mechanical Behavior of Materials, 2022
Many empirical equations have been proposed in the past to predict the parameters of the one-dimensional normal consolidation line (1D-NCL) for soils. However, applications of these equations are limited to specific range of pressure and plasticity soils.
Al-Badran Yasir M., Baille Wiebke, Schanz Tom   +2 more
doaj   +1 more source

The Case for Master Protocols for Rare Neurological Diseases. [PDF]

Ann Neurol
Master protocol trials allow for simultaneous multiple hypothesis testing within a common framework and might be applicable for rare diseases. In May 2025, the Network for Excellence in Neuroscience Clinical Trials convened a multistakeholder conference to discuss master protocol trials in rare neurological disorders.
Vermilion J, Paganoni S, Plotkin SR, Quintana M, Calvert SB, Whiteman IT, Wang RY, Moore N, Augustine EF.   +8 more
europepmc   +2 more sources

Induced expression of nucleolin phosphorylation-deficient mutant confers dominant-negative effect on cell proliferation.

PLoS ONE, 2014
Nucleolin (NCL) is a major nucleolar phosphoprotein that has pleiotropic effects on cell proliferation and is elevated in a variety of tumors. NCL is highly phosphorylated at the N-terminus by two major kinases: interphase casein kinase 2 (CK2) and ...
Shu Xiao, Elif Caglar, Priscilla Maldonado, Dibash Das, Zaineb Nadeem, Angela Chi, Benjamin Trinité, Xin Li, Anjana Saxena   +8 more
doaj   +1 more source

A one base pair deletion in the canine ATP13A2 gene causes exon skipping and late-onset neuronal ceroid lipofuscinosis in the Tibetan terrier. [PDF]

PLoS Genetics, 2011
Neuronal ceroid lipofuscinosis (NCL) is a progressive neurodegenerative disease characterized by brain and retinal atrophy and the intracellular accumulation of autofluorescent lysosomal storage bodies resembling lipofuscin in neurons and other cells ...
Anne Wöhlke, Ute Philipp, Patricia Bock, Andreas Beineke, Peter Lichtner, Thomas Meitinger, Ottmar Distl   +6 more
doaj   +1 more source

Core and π‐Bridge Engineering to Deconstruct Y6‐Series into Modular Non‐Fused Acceptors: DFT‐Guided Structure‐Property Map for Organic Solar Cells

Advanced Electronic Materials, EarlyView.
The rigid fused backbone of Y6‐series acceptors is deconstructed into a modular, non‐fused A‐π‐A′‐π‐A architecture. Comprehensive quantum chemical simulations reveal that strategic core and π‐bridge engineering preserves strong near‐infrared light‐harvesting and enhances intramolecular charge‐transfer character.
Qurat ul Ain, Waqas Akram, Hasan Yaqoob, Munazza Shahid, Abdul Majid, Muhammad Altaf, Christian B. Nielsen, Raja Shahid Ashraf   +7 more
wiley   +1 more source