Results 61 to 70 of about 20,747 (199)

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Dissecting the tRNA Fragment tRF3E–Nucleolin Interaction: Implications in Breast Cancer

Biomolecules
Nucleolin (NCL), an RNA-binding protein which regulates critical cellular processes, is frequently dysregulated in human cancers, including breast cancer, making it an attractive therapeutic target.
Maurizio Falconi, Junbiao Wang, Andrea Costamagna, Mara Giangrossi, Sunday Segun Alimi, Emilia Turco, Massimo Bramucci, Luana Quassinti, Rossana Petrilli, Michela Buccioni, Gabriella Marucci, Augusto Amici, Paola Defilippi, Roberta Galeazzi, Cristina Marchini   +14 more
doaj   +1 more source

A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8

Brain Pathology, EarlyView.
We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren, Carola Hedberg‐Oldfors, Kittichate Visuttijai, Sara Nordström, Hans Goebel, Anders Oldfors   +5 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Correlation of Nucleolin with the Stability and Severity of Coronary Plaque in Acute Coronary Syndrome [PDF]

Zhongguo quanke yixue
Background Acute coronary syndrome (ACS) is a group of pathological clinical syndromes characterized with coronary atherosclerotic plaque rupture or erosion, and secondary complete or incomplete occlusion of thrombosis.
ZHANG Qiongdan, MAO Zhuoni, HUANG Dan, FANG Li
doaj   +1 more source

Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and TFEB‐amplified renal cell carcinoma: a comprehensive study of 15 cases

Histopathology, EarlyView.
This study supports the need for ancillary testing to diagnose ESC‐RCC versus TFEB‐amplified RCC, as neither morphology nor immunohistochemistry is sufficiently specific to distinguish these entities. The underlying molecular drivers in each tumour are pathogenic TSC1 or TSC2 gene variants in ESC‐RCC and TFEB gene amplification in TFEB‐amplified RCC ...
Hayley Zullow, Melissa Y. Tjota, Jung Woo Kwon, Tatjana Antic   +3 more
wiley   +1 more source

Efficient Conversion of Carbohydrates to 5-Hydroxymethylfurfural (HMF) Using ZrCl4 Catalyst in Nitromethane [PDF]

Biofuel Research Journal, 2014
Solvent nitromethane along with a variety of metal chloride and mineral acids as catalyst were studied for the synthesis of 5-Hydroxymethylfurfural (HMF), a key precursor in the formation of alternative fuel 2,5-dimethylfuran (DMF) and other value added ...
Raju S. Thombal, Vrushali H. Jadhav
doaj  

Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Disulfide‐rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80‐residue proteins conserved across gastropods that form a long‐standing orphan family whose structure and biological roles have remained unknown.
Oleg Melnyk, Stéphanie Caby, Armelle Vigouroux, Christine Demanche, Rémi Desmet, Magalie Sénéchal, Benoît Snella, Alexandra Mougel, Céline Boidin‐Wichlacz, Aurélie Parmentier, Ugo Pasco, Sonia Cantel, Solange Moréra, Jérôme Vicogne   +13 more
wiley   +1 more source

Nucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function

Biology Direct
Background Nucleolin (NCL) plays an important regulatory role in angiotensin II (Ang II)-induced phenotypic switching of vascular smooth muscle cells (VSMCs). The aim of this study was to discuss its potential regulatory mechanisms.
Li Fang, Zhijie Shen, Yinzhuang Zhang, Zhuoni Mao, Dan Huang, Chenyu Lou   +5 more
doaj   +1 more source

Mapping the global threat of Mythimna separata (Walker) and its economic implications for Brazil's agriculture

Pest Management Science, Volume 82, Issue 9, Page 9097-9106, September 2026.
Global models identified high‐risk areas for Mythimna separata invasion, highlighting major economic vulnerability for Brazilian crops and guiding targeted prevention and management strategies. Abstract BACKGROUND Identifying high‐risk areas for the introduction of invasive alien species is particularly important for agricultural pests with a broad ...
Gabriel Dorotel da Silva Ferreira, Cesar Augusto Marchioro   +1 more
wiley   +1 more source