Results 41 to 50 of about 35,363 (287)
Contribution of patient organisations to the NCLs
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020 This review will summarise the achievements of Patient Organisations and Foundations started by affected Batten disease families, with an emphasis on their recent contribution to Batten disease, examine the benefits and pitfalls of their interactions with scientists and propose a way forward.
Heather, Band +2 more
openaire +2 more sources
Fragmentation reactions of some aliphatic esters in the NCl(F -) and NCl(NH 2 -) mass spectra [PDF]
, 1984 Grützmacher H-F, Grotemeyer B. Fragmentation reactions of some aliphatic esters in the NCl(F -) and NCl(NH 2 -) mass spectra. Organic Mass Spectrometry.
Grotemeyer, Barbara +1 more
core +1 more source
Transboundary and Emerging Diseases, 2019 Streptococcus suis is a major swine pathogen and an important zoonotic agent worldwide. At least nine serotypes can infect human so far. Although 29 serotypes (1-19, 21, 23-25, 27-31 and 1/2) strains are considered as authentic S.
Jinhu Huang +10 more
semanticscholar +1 more source
Asynchronous Register Less NULL Convention Logic (RL-NCL) Pipeline Architectures Using Basic Gates
Memoria Investigaciones en Ingeniería, 2022 Asynchronous circuits is an alternative to design digital systems that is becoming the interest of many researchers in the digital design area mainly due to it’s low-power consumption and robustness.
Gabriel C. Duarte, Duarte L. Oliveira
doaj +1 more source
Experimental gene therapies for the NCLs
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020 The neuronal ceroid lipofuscinoses (NCLs), also known as Batten disease, are a group of rare monogenic neurodegenerative diseases predominantly affecting children. All NCLs are lethal and incurable and only one has an approved treatment available. To date, 13 NCL subtypes (CLN1-8, CLN10-14) have been identified, based on the particular disease-causing ...
Liu, Wenfei +7 more
openaire +4 more sources
Angewandte Chemie, EarlyView.The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl +4 more
wiley +2 more sources
BMC Bioinformatics, 2019 Background Non-co-linear (NCL) transcripts consist of exonic sequences that are topologically inconsistent with the reference genome in an intragenic fashion (circular or intragenic trans-spliced RNAs) or in an intergenic fashion (fusion or intergenic ...
Chia-Ying Chen, Trees-Juen Chuang
doaj +1 more source
The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68
Molecular Cancer, 2018 Long non-coding RNAs (lncRNAs) function as key molecules in cancer progression. The lncRNA CYTOR plays oncogenic roles in multiple types of cancer, yet the detailed molecular mechanisms of those roles remain unknown.
Xue Wang +9 more
semanticscholar +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Frontiers in ImmunologyObjectives The tumor microenvironment (TME) plays a critical role in the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular composition of the TME in LUAD and assess the role of the MDK-NCL signaling pathway.
Yu Fu +5 more
semanticscholar +1 more source