Results 11 to 20 of about 319,032 (135)

Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach [PDF]

Journal of Virological Methods, 2019
Sequencing very long stretches of the HIV-1 genome can advance studies on virus evolution and in vivo recombination but remains technically challenging.
Demecheleer, Els, Hardy, Jarryt, Hebberecht, Laura, Mortier, Virginie, Schauvliege, Marlies, Staelens, Delfien, Vancoillie, Leen, Verhofstede, Chris   +7 more
core   +3 more sources

A near-telomere-to-telomere genome assembly of the Chinese soft-shelled turtle (Pelodiscus sinensis) [PDF]

Scientific Data
Pelodiscus sinensis (Chinese soft-shelled turtle) is a freshwater species with economic and biomedical value. Here, we report a near-telomere-to-telomere (near-T2T) chromosome-level genome assembly.
Zhe Li, Ruping Zhao, Zi’ao Wang, Lingrui Ge, Qin Qin, Shuting Xiong, Xiaoqing Wang, Yazhou Hu   +7 more
doaj   +2 more sources

Molecular genetic characterization of a novel HIV-1 circulating recombinant form (CRF205_0107) among men who have sex with men in Hangzhou, China [PDF]

Frontiers in Microbiology
IntroductionCirculating recombinant forms (CRFs) play a critical role in the global transmission of HIV-1. In China, where CRF01_AE and CRF07_BC are the predominant circulating strains, second-generation recombinant viruses derived from these two CRFs ...
Ling Ye, Ling Ye, Ke Xu, Ke Xu, Wenjie Luo, Sisheng Wu, Zhou Sun, Xingliang Zhang, Jiafeng Zhang, Qin Fan, Min Zhu, Min Zhu   +11 more
doaj   +2 more sources

Single molecule, near full-length genome sequencing of dengue virus. [PDF]

Sci Rep, 2020
Adikari TN, Riaz N, Sigera C, Leung P, Valencia BM, Barton K, Smith MA, Bull RA, Li H, Luciani F, Weeratunga P, Thein TL, Lim VWX, Leo YS, Rajapakse S, Fink K, Lloyd AR, Fernando D, Rodrigo C.   +18 more
europepmc   +2 more sources

NanoHIV: A Bioinformatics Pipeline for Producing Accurate, Near Full-Length HIV Proviral Genomes Sequenced Using the Oxford Nanopore Technology

Cells, 2021
HIV-1 proviral single-genome sequencing by limiting-dilution polymerase chain reaction (PCR) amplification is important for differentiating the sequence-intact from defective proviruses that persist during antiretroviral therapy (ART).
Imogen A. Wright, Kayla E. Delaney, Mary Grace K. Katusiime, Johannes C. Botha, Susan Engelbrecht, Mary F. Kearney, Gert U. van Zyl   +6 more
doaj   +1 more source

Identification of two near-identical novel HIV-1 unique recombinant forms (CRF01_AE/B) among men who have sex with men in baoding, hebei, China

Frontiers in Genetics, 2023
Men who have sex with men (MSM) are the most frequent infection route of the human immunodeficiency virus (HIV) in Baoding, China, creating chances for the occurrence of unique recombinant forms (URFs) of the virus, i.e., recombination of different ...
Binbin Zhang, Sisi Chen, Juan Meng, Miaomiao Su, Weiguang Fan, Weina An, Xinli Lu   +6 more
doaj   +1 more source

Characterization of two novel HIV-1 second-generation recombinants (CRF01_AE/CRF07_BC) identified in Hebei Province, China

Frontiers in Microbiology, 2023
IntroductionThe unique recombinant forms (URFs) of HIV-1 consist of a mixture of subtypes, and each URF has a unique breakpoint. In this study, we identified the near fulllength genome (NFLG) sequences of two novel HIV-1 URFs (Sample ID: BDD034A and ...
Xuegang Yang, Na Zhao, Miaomiao Su, Juan Meng, Jian Du, Weina An, Haoxi Shi, Weiguang Fan   +7 more
doaj   +1 more source

Emerging PCR-based techniques to study HIV-1 reservoir persistence [PDF]

, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Cole, Basiel, Lambrechts, Laurens, Rutsaert, Sofie, Trypsteen, Wim, Vandekerckhove, Linos   +4 more
core   +2 more sources

Characterization of a Near Full-Length Hepatitis E Virus Genome of Subtype 3c Generated from Naturally Infected South African Backyard Pigs

Pathogens, 2022
Eight genotypes of the hepatitis E virus (Orthohepevirus A; HEV) designated HEV-1 to HEV-8 have been reported from various mammalian hosts. Notably, domestic pigs and wild boars are the natural reservoirs of HEV-3 and HEV-4 genotypes with zoonotic ...
Ravendra P. Chauhan, Michelle L. Gordon
doaj   +1 more source

Statistical mechanics and thermodynamics of viral evolution [PDF]

, 2015
This paper analyzes a simplified model of viral infection and evolution using the 'grand canonical ensemble' and formalisms from statistical mechanics and thermodynamics to enumerate all possible viruses and to derive thermodynamic variables for the ...
Bianco, Simone, Jones, Barbara A., Kaufman, James H., Lessler, Justin   +3 more
core   +13 more sources