Results 91 to 100 of about 5,338 (235)

Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper‐contractility

The Journal of Physiology, Volume 603, Issue 12, Page 3533-3550, 15 June 2025.
Abstract figure legend Graphical representation of the main results. The cartoon indicates that, in the presence of TNNT1 variants, the thin filament is more compliant, and more easily activated leading to higher myofibre Ca2+ sensitivity and cellular hyper‐contractility.
Jenni Laitila, Christopher T. A. Lewis, Anthony L. Hessel, Guido Primiano, Aurelio Hernandez‐Lain, Chiara Fiorillo, Michael W. Lawlor, Coen A. C. Ottenheijm, Heinz Jungbluth, Ka Fu Man, Arianna Fornili, Julien Ochala   +11 more
wiley   +1 more source

EccDNA Analysis Provides Novel Insights Into the Molecular Mechanism of Firmness of Fish Fillet

Food Science &Nutrition, Volume 13, Issue 5, May 2025.
We provide a new and basic eccDNA database for the molecular regulation of muscle firmness in grass carp. The eccDNA abundance in crisp grass carp was significantly higher than that in ordinary grass carp. EccDNAs likely play important roles in the muscle‐hardening of crisp grass carp.
Kai Zhang, Jianchao Chen, Haobin He, Binwei Duan, Canbei You, Zehua Hu, Linhao Cai, Xi Xiang, Rishen Liang   +8 more
wiley   +1 more source

Crossreactive autoantibodies directed against cutaneous and joint antigens are present in psoriatic arthritis. [PDF]

PLoS ONE, 2014
Psoriatic arthritis (PsA) is a chronic inflammatory disease of unknown origin, characterized by erosions and new bone formation. Diagnosis of PsA is mainly clinical and there are no biomarkers available.
Marzia Dolcino, Claudio Lunardi, Andrea Ottria, Elisa Tinazzi, Giuseppe Patuzzo, Antonio Puccetti   +5 more
doaj   +1 more source

Distinct molecular features of FLNC mutations, associated with different clinical phenotypes

Cytoskeleton, Volume 82, Issue 3, Page 158-174, March 2025.
Abstract Filamin С is a key an actin‐binding protein of muscle cells playing a critical role in maintaining structural integrity and sarcomere organization. FLNC mutations contribute to various types of cardiomyopathies and myopathies through potentially different molecular mechanisms.
Klimenko E.S, Zaytseva A.K, Sorokina M.Yu, Perepelina K.I, Rodina N.L, Nikitina E.G, Sukhareva K.S, Khudiakov A.A, Vershinina T.L, Muravyev A.S, Mikhaylov E.N, Pervunina T.M, Vasichkina E.S, Kostareva A.A   +13 more
wiley   +1 more source

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Acta Neuropathologica Communications, 2020
Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden.
Jenni M. Laitila, Elyshia L. McNamara, Catherine D. Wingate, Hayley Goullee, Jacob A. Ross, Rhonda L. Taylor, Robbert van der Pijl, Lisa M. Griffiths, Rachel Harries, Gianina Ravenscroft, Joshua S. Clayton, Caroline Sewry, Michael W. Lawlor, Coen A. C. Ottenheijm, Anthony J. Bakker, Julien Ochala, Nigel G. Laing, Carina Wallgren-Pettersson, Katarina Pelin, Kristen J. Nowak   +19 more
doaj   +1 more source

The effects of gender and muscle type on the mRNA levels of the calpain proteolytic system and beef tenderness during post-mortem aging [PDF]

, 2016
The objective of this study was to determine the effects of gender and muscle type on the mRNA levels of the calpain system and the tenderization of beef meat.
Boccard, Boehm, Choi, Christopher Heinz Hunke Mberema, Cong, Cong, Cross, Dayton, Destefanis, Doumit, Field, Fritsche, Gandolfi, García Díaz, Geesink, Geesink, Georg Lietz, Gheisari, Goll, Hartwig, Huff-Lonergan, Ilian, Ilian, Ilian, Ilias Kyriazakis, Jiang, Keane, Kemp, Kirchofer, Knight, Kramerova, Labrie, Laure, Lomiwes, Morgan, Morgan, Olivier A.E. Sparagano, Ono, Ono, Parr, Parr, Purchas, Raynaud, Sensky, Sorimachi, Sorimachi, Sullivan, Tang, Taylor, Theil, Vandesompele, Walker, Yang, Zhang   +53 more
core   +1 more source

Association between mitochondrial DNA copy number and production traits in pigs

Journal of Animal Breeding and Genetics, Volume 142, Issue 2, Page 170-183, March 2025.
Abstract Mitochondria are essential organelles in the regulation of cellular energetic metabolism. Mitochondrial DNA copy number (mtDNA_CN) can be used as a proxy for mitochondria number, size, and activity. The aims of our study are to evaluate the effect of mtDNA_CN and mitochondrial haploblocks on production traits in pigs, and to identify the ...
Eduard Molinero, Ramona N. Pena, Joan Estany, Roger Ros‐Freixedes   +3 more
wiley   +1 more source

Actin Dynamics in Muscle Cells [PDF]

, 2009
In every cell, actin is a key component involved in migration, cytokinesis, endocytosis and generation of contraction. In non-muscle cells, actin filaments are very dynamic and regulated by an array of proteins that interact with actin filaments and/or ...
Skwarek-Maruszewska, Aneta
core  

Kelch proteins: emerging roles in skeletal muscle development and diseases [PDF]

, 2014
Our understanding of genes that cause skeletal muscle disease has increased tremendously over the past three decades. Advances in approaches to genetics and genomics have aided in the identification of new pathogenic mechanisms in rare genetic disorders ...
Beggs, Alan H, Gupta, Vandana A
core   +1 more source

Alternating electric fields transform the intricate network of tumour vasculature into orderly parallel capillaries and enhance the anti‐angiogenesis effect of bevacizumab

Cell Proliferation, Volume 58, Issue 1, January 2025.
The application of 1000 kHz alternating electric fields effectively suppresses tumour vasculature, transforming it into orderly, parallel straight capillaries. This not only halts the growth of xenograft tumours but also synergistically enhances the therapeutic effects of bevacizumab, offering a promising approach in cancer treatment.
Lin Shen, Shuai Li, Yalin Wang, Yi Yin, Yiting Liu, Yunlei Zhang, Xuesheng Zheng   +6 more
wiley   +1 more source