Results 41 to 50 of about 5,338 (235)

Structure of giant muscle proteins

Frontiers in Physiology, 2013
Giant muscle proteins (e.g. titin, nebulin, and obscurin) play a seminal role in muscle elasticity, stretch response, and sarcomeric organization. Each giant protein consists of multiple tandem structural domains, usually arranged in a modular fashion ...
Nathan Thompson Wright, Logan C. Meyer
doaj   +1 more source

neb: a zebrafish model of nemaline myopathy due to nebulin mutation

Disease Models & Mechanisms, 2012
SUMMARY Nemaline myopathy is one of the most common and severe non-dystrophic muscle diseases of childhood. Patients typically present in infancy with hypotonia, weakness, delayed motor development, and bulbar and respiratory difficulties.
William R. Telfer, Darcee D. Nelson, Trent Waugh, Susan V. Brooks, James J. Dowling   +4 more
doaj   +1 more source

Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone

IUCrJ, 2021
The production of diffraction-quality protein crystals is challenging and often requires bespoke, time-consuming and expensive strategies. A system has been developed in which the BCL6 BTB domain acts as a crystallization chaperone and promiscuous ...
Thomas Zacharchenko, Stephanie Wright
doaj   +1 more source

Proteomic Analysis of a Noninvasive Human Model of Acute Inflammation and Its Resolution: The Twenty-one Day Gingivitis Model [PDF]

, 2010
The 21-day experimental gingivitis model, an established noninvasive model of inflammation in response to increasing bacterial accumulation in humans, is designed to enable the study of both the induction and resolution of inflammation.
Barr, Gordon, Chapple, Iain L. C., Cooper, Helen J., Creese, Andrew J., Grant, Melissa M., Griffiths, Helen R., Ling, Martin R., Matthews, John B., Scott, Ann E.   +8 more
core   +3 more sources

The Nebulin family: an actin support group [PDF]

Trends in Cell Biology, 2011
Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of cytoskeletal structures, and expressed in different tissues. For decades, nebulin has been thought to act as a molecular ruler, specifying the precise length of actin filaments in ...
Christopher T, Pappas, Katherine T, Bliss, Anke, Zieseniss, Carol C, Gregorio   +3 more
openaire   +2 more sources

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

eLife, 2017
Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray.
Andres Ramirez-Martinez, Bercin Kutluk Cenik, Svetlana Bezprozvannaya, Beibei Chen, Rhonda Bassel-Duby, Ning Liu, Eric N Olson   +6 more
doaj   +1 more source

Multi-omic data integration for the study of production, carcass, and meat quality traits in Nellore cattle

Frontiers in Genetics, 2022
Data integration using hierarchical analysis based on the central dogma or common pathway enrichment analysis may not reveal non-obvious relationships among omic data.
Francisco José de Novais, Haipeng Yu, Aline Silva Mello Cesar, Mehdi Momen, Mirele Daiana Poleti, Bruna Petry, Gerson Barreto Mourão, Luciana Correia de Almeida Regitano, Gota Morota, Luiz Lehmann Coutinho   +9 more
doaj   +1 more source

Whole-exome analysis in osteosarcoma to identify a personalized therapy [PDF]

, 2017
Osteosarcoma is the most common pediatric primary non-hematopoietic bone tumor. Survival of these young patients is related to the response to chemotherapy and development of metastases.
Aretini, Paolo, Carletti, Raffaella, Chiappetta, Caterina, Civita, Prospero, De Gregorio, Veronica, DELLA ROCCA, Carlo, DI CRISTOFANO, Claudio, Franceschi, Sara, Lessi, Francesca, Mancini, Massimiliano, Mazzanti, Chiara M., Naccarato, Antonio G., Petrozza, Vincenzo, Puggioni, Chiara   +13 more
core   +1 more source

Effect of Troponin Ca2+ Binding Properties on the Kinetics of Myofibril Force Initiation and Relaxation [PDF]

, 1956
Digitalitzat per ...
Piroddi, Nicoletta, Kreutziger, Kareen L., Scellini, Beatrice, Lundy, Scott, Ferrantini, Cecilia, Tesi, Chiara, Regnier, Michael, Poggesi, Corrado   +7 more
core   +1 more source

Nemaline myopathy: clinical, histochemical and immunohistochemical features Miopatia nemalínica: achados clínicos, histoquímicos e imuno-histoquímicos

Arquivos de Neuro-Psiquiatria, 2009
Nemaline myopathy (NM) is a congenital disease that leads to hypotonia and feeding difficulties in neonates. Some cases have a more benign course, with skeletal abnormalities later in life.
Nazah Cherif Mohamad Youssef, Rosana Herminia Scola, Paulo José Lorenzoni, Lineu César Werneck   +3 more
doaj   +1 more source