Results 51 to 60 of about 5,338 (235)
Nature Communications, 2020 Nebulin-based nemaline myopathy is a heterogenous disease with unclear pathological mechanisms. Here, the authors generate a mouse model that mimics the most common genetic cause of the disease and demonstrate that muscle weakness in this model is ...
Johan Lindqvist +15 more
doaj +1 more source
Nebulin no longer nebulous [PDF]
Journal of General Physiology, 2018 JGP study probes how nebulin affects muscle function.
openaire +1 more source
Identification of marbling-related candidate genes in M-longissimus dorsi of high- and low marbled Hanwoo (Korean native cattle) steers [PDF]
, 2008 This study was conducted to identify marbling-related candidate genes in M. longissimus dorsi of high- and low-marbled Hanwoo. The longissimus dorsi muscles were selected for gene expression from eight Hanwoo steer carcasses based on crude fat content ...
Cho, Yong-Min +10 more
core +1 more source
Nebulin doesn't measure up [PDF]
Journal of Cell Biology, 2010 ![Figure][1] Nebulin (red) stabilizes actin filaments (green) to protect them from latrunculin A. In the protein’s absence (right), the depolymerizing drug causes filament disassembly.
openaire +1 more source
Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei [PDF]
, 2017 The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis.
Baqui, Munira M.A. +3 more
core +1 more source
Stem Cell Research, 2020 Nemaline myopathy-2 (NEM2) is an autosomal recessive skeletal muscle disorder caused by mutations in the nebulin (NEB) gene. We report the generation and characterization of a human induced pluripotent stem cell (iPSC) line SDQLCHi017-A, derived from a 1-
Yanyan Ma +8 more
doaj +1 more source
The LIM and SH3 domain protein family: structural proteins or signal transducers or both?
Molecular Cancer, 2008 LIM and SH3 Protein 1 (LASP-1) was initially identified from a cDNA library of metastatic axillary lymph nodes (MLN) more than a decade ago. It was found to be overexpressed in human breast and ovarian cancer and became the first member of a newly ...
Butt Elke, Grunewald Thomas GP
doaj +1 more source
Functional Classification of Skeletal Muscle Networks. I. Normal Physiology [PDF]
, 2012 Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models.
Subramaniam, Shankar +2 more
core +2 more sources
Nebulin: A Study of Protein Repeat Evolution
Journal of Molecular Biology, 2010 Protein domain repeats are common in proteins that are central to the organization of a cell, in particular in eukaryotes. They are known to evolve through internal tandem duplications. However, the understanding of the underlying mechanisms is incomplete. To shed light on repeat expansion mechanisms, we have studied the evolution of the muscle protein
Björklund, Åsa K. +3 more
openaire +3 more sources
Capturing coevolutionary signals in repeat proteins [PDF]
, 2014 The analysis of correlations of amino acid occurrences in globular proteins has led to the development of statistical tools that can identify native contacts -- portions of the chains that come to close distance in folded structural ensembles.
Espada, Rocío +4 more
core +5 more sources