Results 71 to 80 of about 5,338 (235)

The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI‐α and Controls Myogenic Differentiation

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Muscle RING finger (MuRF) proteins are striated muscle‐specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabilization, influencing muscle differentiation and function.
Ning Li, Jida Hamati, Yi Li, Björn Brinschwitz, Mohamed Ghait, Elisa Martin, Dörte Lodka, Elke Hammer, Britta Fielitz, Uwe Völker, Gunnar Dittmar, Thomas Sommer, Friedrich C. Luft, Jens Fielitz   +13 more
wiley   +1 more source

Correction to: Expressing a Z-disk nebulin fragment innebulin-deficient mouse muscle: effects on muscle structure and function

Skeletal Muscle, 2020
Following the publication of this paper [1], it was brought to the authors’ attention that one of the contributing authors was left off of the paper. The authors apologize for the unfortunate oversight.
Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith, Jeffrey S. Chamberlain, Henk Granzier   +7 more
doaj   +1 more source

Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms [PDF]

, 2017
We have studied a cohort of nemaline myopathy (NM) patients with mutations in the muscle α-skeletal actin gene (ACTA1). Immunoblot analysis of patient muscle demonstrates increased γ-filamin, myotilin, desmin and α-actinin in many NM patients, consistent
Clement, Sophie, Cooper, Sandra T., Davies, Kay E., Domazetovska, Ana, Ilkovski, Biljana, Laing, Nigel G., Maxwell, Adam L., North, Kathryn N., Nowak, Kristen J.   +8 more
core  

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin [PDF]

, 2022
In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the underlying mechanism remains nebulous. In this work, we used cryo-electron tomography and subtomogram averaging to reveal structures of native nebulin bound to ...
Gautel, M., Grange, M., Kho, A., Pospich, S., Raunser, S., Wagner, T., Wang, Z.   +6 more
core   +3 more sources

Dry‐Aged Beef: A Global Review of Meat Quality Traits, Microbiome Dynamics, Safety, and Sustainable Strategies

Journal of Food Science, Volume 90, Issue 10, October 2025.
ABSTRACT Dry‐aged beef is valued for its tenderness, complex aroma, and concentrated flavor. However, variability in aging protocols and limited understanding of underlying biological and technological processes can compromise consistent quality and safety.
Ana J. Ribeiro, Filipe Silva, Paula Teixeira, Cristina M. Saraiva   +3 more
wiley   +1 more source

Usher syndrome and Nebulin‐associated myopathy in a single patient due to variants in MYO7A and NEB

Clinical Case Reports, 2020
In a patient with Usher syndrome and atypical muscle complaints, we have identified two separate variants in MYO7A andNEB genes by exome sequencing. The homozygous variants in these two recessive genes could explain the full phenotype of our patient.
Nuno Maia, Ana Rita Soares, Ana Maria Fortuna, Isabel Marques, Ana Gonçalves, Rosário Santos, Manuel Melo Pires, Arjan P. M. de Brouwer, Paula Jorge   +8 more
doaj   +1 more source

Formation and inhibition mechanism of novel angiotensin I converting enzyme inhibitory peptides from Chouguiyu

Frontiers in Nutrition, 2022
Angiotensin I converting enzyme (ACE) inhibitory peptides from fermented foods exhibit great potential to alleviate hypertension. In this study, the peptide extract from Chouguiyu exhibited a good inhibition effect on ACE, and the inhibition rate was ...
Daqiao Yang, Daqiao Yang, Daqiao Yang, Laihao Li, Laihao Li, Laihao Li, Chunsheng Li, Chunsheng Li, Chunsheng Li, Shengjun Chen, Shengjun Chen, Shengjun Chen, Jianchao Deng, Jianchao Deng, Jianchao Deng, Shaoling Yang, Shaoling Yang, Shaoling Yang   +17 more
doaj   +1 more source

Cellular and molecular mechanisms underlying muscular dystrophy [PDF]

, 2014
The muscular dystrophies are a group of heterogeneous genetic diseases characterized by progressive degeneration and weakness of skeletal muscle. Since the discovery of the first muscular dystrophy gene encoding dystrophin, a large number of genes have ...
Kunkel, Louis M., Rahimov, Fedik
core   +1 more source

Different Lower Limb Muscle MRI Patterns in Autosomal Dominant Titinopathies

European Journal of Neurology, Volume 32, Issue 10, October 2025.
ABSTRACT Background and Purpose Titin is critical for sarcomere structure and function, and mutations in this gene cause titinopathies, a group of neuromuscular disorders. Muscle MRI is a key tool for diagnosing and understanding these conditions.
David Gómez‐Andrés, Laura Costa‐Comellas, Jordi Díaz‐Manera, Katrin Õunap, Mireia Álvarez‐Molinero, Gabriela Urcuyo, Marco Savarese, Francina Munell, Bjarne Udd   +8 more
wiley   +1 more source

An integrated diagnosis strategy for congenital myopathies. [PDF]

PLoS ONE, 2013
Congenital myopathies are severe muscle disorders affecting adults as well as children in all populations. The diagnosis of congenital myopathies is constrained by strong clinical and genetic heterogeneity. Moreover, the majority of patients present with
Johann Böhm, Nasim Vasli, Edoardo Malfatti, Stéphanie Le Gras, Claire Feger, Bernard Jost, Nicole Monnier, Julie Brocard, Hatice Karasoy, Marion Gérard, Maggie C Walter, Peter Reilich, Valérie Biancalana, Christine Kretz, Nadia Messaddeq, Isabelle Marty, Joël Lunardi, Norma B Romero, Jocelyn Laporte   +18 more
doaj   +1 more source