Results 41 to 50 of about 118,017 (304)
NEC distribution in transfected HeLa cells with modest NEC production.
, 2021 HeLa cells were co-transfected with the expression plasmids indicated on the left of the panel. At 18 hours post transfection, cells were fixed and nuclei were stained with Hoechst 33342.
Bruce W. Banfield (11320810) +4 more
core +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Advanced Science, EarlyView.GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han +16 more
wiley +1 more source
Unsupervised Qualitative Scoring for Binary Item Features
Data Science and Engineering, 2020 Binary features, such as categories, keywords, or tags, are widely used to describe product properties. However, these features are incomplete in that they do not contain several aspects of numerical information.
Koji Ichikawa, Hiroshi Tamano
doaj +1 more source
Machine learning autonomous identification of magnetic alloys beyond the Slater-Pauling limit
Communications Materials, 2021 Finding materials with large magnetization is highly desirable for technological applications. Here, a machine learning autonomous search and automated combinatorial synthesis reveal that multi-element alloys with Ir and Pt impurities have a ...
Yuma Iwasaki +3 more
doaj +1 more source
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
Advanced Science, EarlyView.High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao +11 more
wiley +1 more source
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
Derecho & Sociedad, 2020 En los últimos años se viene haciendo referencia a los contratos “colaborativos” en América Latina. Sin embargo, no existe un entendimiento común sobre qué significa dicho término, la discusión y desarrollo internacional que hay detrás.
Franco Regjo, Eric
doaj
Proposal of the pipe diagnosis method using in-plane bending vibration of cylindrical shell
Nihon Kikai Gakkai ronbunshu, 2018 In this paper, deterioration diagnosis for distribution main pipe was studied using the uniform cylindrical shell approximation and in-plane bending mode.
Soichiro TAKATA +2 more
doaj +1 more source