Results 61 to 70 of about 118,017 (304)

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Utility of GutCheck-NEC and e-NEC Scoring Systems in Assessing the Risk of Necrotizing Enterocolitis in Preterm Infants

Introduction: Necrotizing enterocolitis (NEC) is one of the leading gastrointestinal emergencies causing significant morbidity and mortality in premature neonates. This study aimed to evaluate the effectiveness of the GutCheck-NEC (GCN) and e-NEC scoring
Oruncu, Berna Egehan, Hırfanoğlu, İbrahim Murat, Berna Egehan Örüncü, Nuriye Ebru Ergenekon, Canan Türkyılmaz, Eray Esra Önal, Ergenekon, Nuriye Ebru, İbrahim Murat Hirfanoğlu, Koç, Esin, Esin Koç, Önal, Eray Esra, Türkyılmaz, Canan   +11 more
core   +1 more source

Giovanni Antonio Scopoli's De Hydrargyro Idriensi Tentamina (1761): Mercury Mining, Mercurialism, and Preventive Reasoning in Eighteenth‐Century Occupational Medicine

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Giovanni Antonio Scopoli (1723–1788), a physician‐naturalist of the Enlightenment, is primarily remembered for his contributions to botany and entomology. Less attention has been paid to his medical work De hydrargyro Idriensi Tentamina physico‐chymico‐medica (1761), written during his fifteen years of service as physician at the mercury mines
Alberto Zanatta, Paola Mason, Sofia Bollini, Giovanni Magno   +3 more
wiley   +1 more source

Emergency and routine presentation of neuroendocrine neoplasia in England: determinants of late presentation and survival outcomes

Endocrine Oncology
Objective: The time from onset of symptoms of neuroendocrine neoplasia (NEN) to diagnosis ranges between 5 and 7 years. Risk factors associated with this and the difference in overall survival (OS) between routine and emergency presentation (RP and EP ...
Marie Line El Asmar, Mohamed Mortagy, Benjamin E White, Dan Burns, John Ramage   +4 more
doaj   +1 more source

NEC-SUP_UL31 and NEC-DN_UL34/SUP_UL31 form hex_AB lattices in the crystals.

A) The HSV-1 WT NEC hexAB (PDB ID: 4ZXS), b) the WT NEC hexCD (PDB ID: 4ZXS), c) the NEC-SUPUL31 and d) the NEC-DNUL34/SUPUL31 crystal lattices [24]. Hexameric (teal) and interhexameric (dimer1: coral, dimer2: gold, trimer1: red, and trimer2: light pink)
Ekaterina E. Heldwein (12975804), Amber Vu (17797698), Hui Wang (30400), Gonzalo L. Gonzalez-Del Pino (17797701), Elizabeth B. Draganova (13021611), Melanie Wu (11429713), Shiqing Liao (17797695), Z. Hong Zhou (190406), Richard J. Roller (17797704)   +8 more
core   +1 more source

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva, Samagra Jain, Rita Snyder, Erin L. McKean, Ralph Abi Hachem, Nithin D. Adappa, J. Ken Byrd, Ricardo L. Carrau, Marc A. Cohen, Ivan H. El‐Sayed, Mathew N. Geltzeiler, Ehab Y. Hanna, Edward C. Kuan, Nyall R. London Jr., Zoukaa B. Sargi, Carl H. Snyderman, Marilene B. Wang, Ian J. Witterick, Shirley Y. Su   +18 more
wiley   +1 more source

Healing Following Endoscopic Reconstruction of the Anterior Skull Base in Patients With Sinonasal Malignancies

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Healing dynamics after anterior skull base (ASB) reconstruction following transnasal endoscopic surgery (TES) for sinonasal malignancies remain poorly characterized. This study aimed to describe the postoperative healing process, quantify time to healing, identify factors influencing healing, and assess radiologic evolution over ...
Giacomo Contro, Leonardo Calvanese, Piergiorgio Gaudioso, Stefano Taboni, Mosè Sozzi, Gloria Schiavo, Alessandra Sordi, Isabelle Dohin, Francesca Mularoni, Giuseppe Roccuzzo, Ester Orlandi, Barbara Vischioni, Gianluca Dalfino, Carlotta Pessina, Roberto Maroldi, Mario Turri‐Zanoni, Cesare Piazza, Paolo Battaglia, Maurizio Bignami, Paolo Castelnuovo, Davide Mattavelli, Piero Nicolai, Marco Ferrari   +22 more
wiley   +1 more source

AI-guided epitope engineering of a SARS-CoV-2 spike antigen for broad sarbecovirus neutralization

Frontiers in Immunology
The rapid evolution of SARS-CoV-2 and the ongoing risk of zoonotic spillover highlight the need for vaccines that provide broad protection beyond strain-specific immunity.
Alexandru Odainic, Ioannis Vardaxis, Matheus Ferraz, Katrin E Wiese, Lisette A H M Cornelissen, Akhilesh Sharma, Richard Stratford, Trevor Clancy, Kaïdre Bendjama, Kaïdre Bendjama   +9 more
doaj   +1 more source

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

NEC rings

Filomat, 2018
A ring R is called NEC if for any a, b ? N(R), ab = ba. The class of NEC rings is a proper generalization of the class of CN rings. First, with the aid of NEC rings, some characterizations of CN rings and reduced rings are given. Next we extend many properties of CN rings to NEC rings such as we show that NEC rings are directly finite and ...
Pan, Yong, Li, Decai, Wei, Junchao
openaire   +3 more sources