Necator americanus Ancylostoma secreted protein-2 (Na-ASP-2) selectively binds an ascaroside (ascr#3) [PDF]
bioRxiv, 2020 During their infective stages, hookworms release excretory-secretory (E-S) products, including small molecules and proteins, to help evade and suppress the host’s immune system.
Ola El Atab +6 more
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Risk profiling and efficacy of albendazole against the hookworms Necator americanus and Ancylostoma ceylanicum in Cambodia to support control programs in Southeast Asia and the Western Pacific. [PDF]
Lancet Reg Health West Pac, 2021 Colella V +7 more
europepmc +2 more sources
Identification of genetic variations in Necator americanus through resequencing by whole genome amplification. [PDF]
J Int Med Res, 2019 Objective To describe a new strategy for the whole genome resequencing of small parasite samples. Methods Whole genome resequencing was based on a multiple displacement amplification (MDA) method.
Liu Y +16 more
europepmc +2 more sources
Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial. [PDF]
Lancet Infect Dis, 2021 Chapman PR +10 more
europepmc +2 more sources
Molecular modelling and de novo fragment-based design of potential inhibitors of beta-tubulin gene of Necator americanus from natural products. [PDF]
Inform Med Unlocked, 2021 Agyapong O +6 more
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Revista de la Facultad de Medicina, 2017 Introducción. La técnica de Kato Katz es el método recomendado para realizar el recuento de huevos en materia fecal y determinar la intensidad parasitaria por helmintos.
Angélica Knudson-Ospina +5 more
doaj +2 more sources
Development and evaluation of a Loop Mediated Isothermal Amplification (LAMP) technique for the detection of hookworm (Necator americanus) infection in fecal samples. [PDF]
Parasit Vectors, 2015 Hookworm infection is a major concern in sub-Saharan Africa, particularly in children and pregnant women. Necator americanus and Ancylostoma duodenale are responsible for this condition.
Mugambi RM +5 more
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Basophil Competence during Hookworm (Necator americanus) Infection [PDF]
The American Journal of Tropical Medicine and Hygiene, 2007 A popular hypothesis to explain parasite survival in the presence of a pronounced T helper 2 phenotype in helminth-parasitized populations has been FcϵRI blockade by parasite-induced polyclonal IgE. To begin to test the hypothesis that FcϵRI-bearing cells would be refractory to activation in parasitized populations, we investigated basophil function in
David I. Pritchard +5 more
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Characterisation of Necator americanus excretory/secretory products
, 2021 Jayden Logan studied the excretory/secretory proteins from the human hookworm. He made some of these proteins outside of the worm and tested them in inflammatory models of disease. One of these proteins selectively suppressed the production of inflammatory cytokines. These results provide potential candidates for treating immune diseases.
Jayden Logan
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