Results 161 to 170 of about 34,308 (261)

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, EarlyView.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

Identification of key programmed cell death genes-necroptosis-related genes in systemic lupus erythematosus. [PDF]

Clin Exp Med
Wang L, Li Y, Liu X, Song S, Han Y, Mo L, Li H, Wang X, Pan Y, Sun J, Wang J.   +10 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Necroptosis in SJS/TEN: <i>RIPK1</i> and <i>RIPK3</i> Expression and Implications for Disease Pathogenesis. [PDF]

Curr Issues Mol Biol
Sooranahalli C, Bouchard C, Iqbal O.
europepmc   +1 more source

Integrated Single‐Cell RNA Sequencing and Untargeted Metabolomics Reveals β‐Elemene's Immune and Metabolic Modulation in Triple‐Negative Breast Cancer

MedComm – Oncology, Volume 5, Issue 3, September 2026.
In a 4T1 TNBC model, β‐elemene suppressed tumor growth and pulmonary metastasis. scRNA‐seq showed it remodeled the tumor microenvironment by reducing cancer‐associated fibroblasts, enhancing antigen presentation, and inhibiting pro‐tumorigenic ECM remodeling. Metabolomics revealed prostaglandin downregulation.
Zhiqiang Luo, Guohua Yu, Huixia Fan, Ruofan Guo, Jingqi Zheng, Chen Wang, Ruyi Jin, Junhui Zhou, Jian Yang   +8 more
wiley   +1 more source

Focus on necroptosis: its role in the pathogenesis and therapeutic potential of osteoarthritis. [PDF]

Front Immunol
Ouyang Y, Liao H, Kang W, Li F, Shen H.
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Toxicarioside H induces cytoprotective autophagy by hindering the progression of necroptosis in triple-negative breast cancer cells. [PDF]

Transl Oncol
Xiong W, Tan GH, Chen H, Chen MH, Wu RH, Dai SZ, Song T, He GS, Zheng WP, Huang FY.   +9 more
europepmc   +1 more source

Necroptosis regulator [PDF]

Nature Immunology, 2015
openaire   +1 more source

Syntaxin 12 Sustains Endosomal‐Lysosomal Homeostasis and Survival in Glioblastoma Stem‐Like Cells

Traffic, Volume 27, Issue 3, September 2026.
Syntaxin12 maintains endolysosomal trafficking and lysosomal homeostasis in glioblastoma cells. Syntaxin12 depletion disrupts lysosomal organization, impairs endolysosomal progression and mTOR‐lysosome communication, and compromises adaptive pathways required for cell survival. ABSTRACT Glioblastoma cells display a striking vulnerability to disruptions
Clément Maghe, Agnieszka Barbach, Gwennan André‐Grégoire, Clotilde C. N. Renaud, Margaux Le Guyon, Rosalie Moreau, Nicolas Bidère, Julie Gavard   +7 more
wiley   +1 more source