Results 161 to 170 of about 8,424,658 (307)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Training needs analysis of surgical teams in Somaliland. [PDF]

Br J Surg
McKnight G, Daoud HA, Friebel R, Hargest R.   +3 more
europepmc   +1 more source

Interprofessional Needs Analysis and User-Centred Prototype Evaluation as a Foundation for Building Individualized Digital Education in Dementia Healthcare Supported by Artificial Intelligence: A Study Protocol. [PDF]

Healthcare (Basel), 2023
Malek M, Nitsche J, Dinand C, Ehlers J, Lissek V, Böhm P, Derksen EM, Halek M.   +7 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Need-based Evaluation Of An Oral Presentation Course At Bejaia University: Perspectives And Considerations

The Journal of Studies in Language, Culture and Society
This paper reports on a needs-based study conducted to explore EFL master students‟ academic needs and to examine the adequacy and effectiveness of the oral presentation course in catering to those needs.
Amina Kimouche, Nadia Idri
doaj  

Developing a competence framework for gerontological nursing in China: a two-phase research design including a needs analysis and verification study. [PDF]

BMC Nurs, 2022
Dijkman BL, Hirjaba M, Wang W, Palovaara M, Annen M, Varik M, Cui Y, Li J, van Slochteren C, Jihong W, Feiteng C, Luo Y, Chen Y, Paans W.   +13 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A gaps-and-needs analysis of vaccine R&D in Europe: Recommendations to improve the research infrastructure. [PDF]

Biologicals, 2022
Jungbluth S, Depraetere H, Slezak M, Christensen D, Stockhofe N, Beloeil L.   +5 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Status and Needs Analysis of Korean Medicine Doctors' Continuing Professional Development. [PDF]

J Pharmacopuncture
Cho EB, Lee JC, Kim EJ, Jo HJ, Kim SK, Oh YT, Hong JS, Choi SH, Shim SB.   +8 more
europepmc   +1 more source