Results 111 to 120 of about 39,677 (245)

HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function

Journal of Virology
HIV-1 accessory protein Nef is a multifunctional pathogenic factor that mediates immune evasion, enhances virion infectivity, antagonizes host restrictive factors, and promotes viral dissemination.
Tian-Jiao Fan, Chengzuo Xie, Lisha Li, Xia Jin, Jie Cui, Jian-Hua Wang   +5 more
doaj   +1 more source

High levels of anti‐Nef antibodies may prevent AIDS disease progression in vertically HIV‐1‐infected infants

Journal of the International AIDS Society, 2014
Introduction HIV‐1‐associated CD4+ T‐cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of
Guillermo Corró, Cintia Milena Crudeli, Carlos Alberto Rocco, Silvia Alejandra Marino, Luisa Sen   +4 more
doaj   +1 more source

Speech Biomarkers for Quantifying Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease

Annals of Neurology, Volume 100, Issue 3, Page 628-640, September 2026.
Objective Dysarthria is one of the most common and disabling side effects of subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD). Stimulation often exacerbates speech dysfunction beyond the effects of PD progression, likely because of current spread to structures surrounding the STN.
Petr Krýže, Mário Sousa, Vojtěch Illner, Adriana Jorge, Matilde Castelli, Ines Debove, Andreia D. Magalhães, Julia Waskönig, Lenard Lachenmayer, Joan Philipp Michelis, Gerd Tinkhauser, Deborah Amstutz, Marie Elise Maradan‐Gachet, Katrin Petermann, Claudio Pollo, Tobias Nef, Paul Krack, Jan Rusz   +17 more
wiley   +1 more source

The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells

Vaccine Research, 2020
Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani, Fatemeh Rouhollah, Maryam Naseroleslami, Azam Bolhassani   +3 more
doaj  

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.

PLoS ONE, 2013
Recent studies in the SIV-macaque model of HIV infection suggest that Nef-specific CD8+ T-cell responses may mediate highly effective immune control of viraemia.
Emily Adland, Jonathan M Carlson, Paolo Paioni, Henrik Kløverpris, Roger Shapiro, Anthony Ogwu, Lynn Riddell, Graz Luzzi, Fabian Chen, Thambiah Balachandran, David Heckerman, Anette Stryhn, Anne Edwards, Thumbi Ndung'u, Bruce D Walker, Søren Buus, Philip Goulder, Philippa C Matthews   +17 more
doaj   +1 more source

Biology of HIV-Nef in vivo [PDF]

, 2007
HIV-Nef is established as an important factor for pathogenicity during HIV infection. The exact role and underlying mechanisms however are still unclear.
Koenen, P.G.F.
core   +14 more sources

Nef-induced Alteration of the Early/Recycling Endosomal Compartment Correlates with Enhancement of HIV-1 Infectivity

, 2004
Human immunodeficiency virus type 1 (HIV-1) Nef interacts with the clathrin-associated AP-1 and AP-3 adaptor complexes, stabilizing their association with endosomal membranes. These findings led us to hypothesize a general impact of this viral protein on
Douglas Hitchin, Hitchin, Douglas, Katy Janvier, Serge Benichou, John Day, Scott Coleman, Benichou, Serge, John Guatelli, Colleen Noviello, Jerome Bouchet, Rodríguez González, Ricardo, Alexandre Benmerah, Ricardo Madrid, Guatelli, John, Day, John, Benmerah, Alexandre, Noviello, Colleen, Bouchet, Jerome, Janvier, Katy, Coleman, Scott   +19 more
core   +1 more source

AutoCAD Nef . . .

, 2007
We present a didactical system for learning and exploring Nef polyhedra and the implementation of an AutoCAD entity representing a Nef polyhedron.
Jeremy Tammik
core  

Identification of Nef region interacting with ASK1.

, 2013
(A) Using Nef core domain (57-207 aa) sequences, two distinct Nef truncations were designed for mammalian two hybrid studies by successively deleting 33 aa form C-terminal and subsequent cloning in pACT vector so as to obtain Nef (57-174 aa), Nef (57-141
Smrati Bhadauria (422141), Ranjana K. Kanchan (422138), Chakrapani Tripathi (422137), Raj Kamal Tripathi (111947), Balawant Kumar (422136), Jitendra Kumar Tripathi (422139), Jimut K. Ghosh (422140), Ravishankar Ramachandran (13206)   +7 more
core   +1 more source

A 40.68‐MHz Active Rectifier Using PLL and PWM Control of DC‐DC Converter for ON/OFF Delay Compensation

International Journal of Circuit Theory and Applications, Volume 54, Issue 9, Page 4469-4481, September 2026.
A ramp‐based phase‐locked loop (RPLL) active rectifier operating at 40.68 MHz compensates switching delay variations to improve phase alignment. The proposed architecture achieves 90.3% peak power conversion efficiency and 98.0% voltage conversion ratio for high‐frequency wireless power transfer in implantable medical devices.
Woorim Lee, Sungmin Shin, Seongbin Kwon, Geonwoo Baek, Jongyeop Kim, Franklin Bien   +5 more
wiley   +1 more source