Results 121 to 130 of about 39,677 (245)

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Scientific Reports, 2017
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold   +8 more
doaj   +1 more source

Identification of a Novel Small Molecule Facilitating HIV Elimination by the “Shock‐And‐Kill” Approach

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Antiretroviral therapy (ART) has markedly improved the prognosis of people living with HIV (PLWH); however, latent viral reservoirs remain a major barrier to a cure. The “Shock and Kill” strategy aims to reactivate latent provirus with latency‐reversing agents (LRAs) and subsequently eliminate the infected cells, yet most LRAs characterized to
Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi   +7 more
wiley   +1 more source

Nef-mediated CTLA-4 down-regulation.

, 2013
Transient co-expression of CTLA-4 and Nef in 293T cells. a) Left panels: Surface expression of CTLA-4 analyzed by FACS following staining of 293T cells co-transfected with CTLA-4 and either Nefneg or Nefwt vectors.
Rabih Halwani (287270), Mohamed El-Far (141824), Yoav Peretz (141817), Rafick-Pierre Sékaly (118474), Jean-Pierre Routy (118465), Elias K. Haddad (141833), Gordon J. Freeman (267166), Olivier Schwartz (15284), Catherine Isabelle (287264), Nicolas Chomont (175516), Martin Bourbonnière (287265), Younes Chouikh (287268), Simone Fonseca (287266), Petronela Ancuta (93066), Joaquín Madrenas (163511)   +14 more
core   +1 more source

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

MedComm, Volume 7, Issue 9, September 2026.
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu   +5 more
wiley   +1 more source

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, Volume 4, Issue 3, Page 275-294, September 2026.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source

Occurrence of Bryde's and Fin Whale Calls and Their Temporal Overlap With Anthropogenic Noise Off El Hierro, Canary Islands (April 2018)

Marine Mammal Science, Volume 42, Issue 4, October 2026.
Susannah J. Buchan, Jesús Alcázar‐Treviño, Miriam Romagosa, Eugenio Fraile Nuez   +3 more
wiley   +1 more source

Clionaidae From Northeastern Brazil: A New Species of Clionaopsis (Rützler 2002), Redescription of Spheciospongia symbiotica (Hechtel 1983), and New Records of Cervicornia cuspidifera (Lamarck 1815)

New Zealand Journal of Zoology, Volume 53, Issue 3, September 2026.
The family Clionaidae d’Orbigny, 1851, includes excavating sponges characterized by tylostyles and a diverse range of microscleres, including spirasters, amphiasters, microxeas, spiral microstrongyles, and derivatives lacking altogether. Despite recent taxonomic advances, generic boundaries within the family remain problematic due to overlapping ...
Elielton F. Nascimento, Renan V. Bento, Ulisses Pinheiro   +2 more
wiley   +1 more source

Focus on DnaJ protein research from Arabidopsis to crop improvement

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract DnaJ proteins (Hsp40s) are essential components of the cellular proteostasis network, functioning as molecular co‐chaperones that regulate protein folding, stability, and stress‐responsive homeostasis in plants. Beyond their classical role as Hsp70 partners, accumulating evidence demonstrates that DnaJ proteins participate in diverse ...
Muhammad Arif, Hafiz Mamoon Rehman, Sehrish Bashir, Noman Mahmood, Atul Kumar Srivastava, Yakov Kuzyakov, Moh Sajid Ansari, Hon‐Ming Lam, Mingfang Yang   +8 more
wiley   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, Volume 293, Issue 18, Page 5541-5557, September 2026.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

Determinants of Sustainable Finance Flows: A Literature Review

Journal of Economic Surveys, Volume 40, Issue 4, Page 2251-2266, September 2026.
ABSTRACT Sustainable finance is defined as capital mobilized that explicitly integrate environmental, social, and governance (ESG) objectives alongside traditional financial metrics. It differs from conventional finance in their dual pursuit of financial and sustainability outcomes.
Akin A. Cilekoglu, Fatih Yilmaz
wiley   +1 more source