Results 111 to 120 of about 246,906 (293)
The syntax of emphatic negation in Modern Irish
GlossaIn this paper I argue, following proposals by Laka (1990), Aboh (2010), De Clercq (2013; 2020a), and Greco (2019; 2020ab) among others, that negation has a dedicated position in the left periphery where it takes wide scope over the lower sentential ...
Nicola D'Antuono
doaj +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Complex & Intelligent SystemsNegation provides a novel perspective for the representation of information. However, current research seldom addresses the issue of negation within the random permutation set theory.
Yongchuan Tang +4 more
doaj +1 more source
Sentence negation in the local dialects of the Čabar area,
Hrvatski Dijalektološki ZbornikSyntactic negation is divided into sentence negation and partial negation. Sentence negation through a negated predicate negates the sentence content completely, while partial negation negates the content of a non-predicate member of the sentence ...
Iva Nazalević Čučević +1 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 2003 Argumentation has proved a useful tool in defining formal semantics for assumption-based reasoning by viewing a proof as a process in which proponents and opponents attack each others arguments by undercuts (attack to an argument's premise) and rebuts ...
Michael Schroeder +3 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Focus and negation in Italian why-questions
GlossaIn the present study, we investigate whether negation interacts with the set of alternatives that are elicited by why-questions. More precisely, we examine whether negation modifies the so-called contrast-class (set of alternatives) in the same way as ...
Cristiano Chesi +3 more
doaj +2 more sources