Results 111 to 120 of about 36,760 (309)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Phenomenology and Mind, 2017 We present the results of an experimental study that aims at establishing whether the offensive component of slurs exhibits nondisplaceability (Potts 2007). We found that the derogatory content survives in conditionals and questions (supporting a pragmatic approach), and diminishes in indirect reports (in line with presuppositional accounts ...
PANZERI, FRANCESCA, Carrus, S.
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Baltistica, 2011 THE WAYS OF EXPRESSING NEGATION IN BALTIC AND SLAVIC LANGUAGESSummaryThe paper is concerned with negation as the universality of language. The content of the given category is determined, and the two ways of its expression in the Russian and Lithuanian ...
Елена Генриховна Казимянец
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Distinguishing Entailment and Presupposition Under Negation Test
LLT Journal: A Journal on Language and Language Teaching, 2016 Distinguishing entailment from presupposition is quite difficult because their semanticrelation seems to be similar. Both entailment and presupposition have an automaticrelationship based on the context.
Gatri Asti Putri Indarti
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The acquisition of negation by L2 German L1 Italian speaker. [PDF]
openThis thesis investigates the acquisition of negation in German by native Italian speaker (L1 Italian) learning German as a second language (L2). The study focuses on high school students in Padua, employing a translation test to collect data on their
FREDDI, MARTA
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Analyzing Iraqi University EFL Learners’ Recognition of Implicit Negation in English Language
مجلة جامعة الأنبار للعلوم الإنسانيةNegation has been a challenging and difficult subject for philosophers, logicians and linguists alike. As a form of negation, implicit (implied, hidden, indirect) negation is a common type that would occur when lexical items, including different parts of
Hafedh Ibraheem Shabeeb
doaj +1 more source