Results 101 to 110 of about 13,221 (154)

A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury. [PDF]

Neurobiol Learn Mem, 2018
Titus DJ, Wilson NM, Alcazar O, Calixte DA, Dietrich WD, Gurney ME, Atkins CM.   +6 more
europepmc   +1 more source

The action of a negative allosteric modulator at the dopamine D₂ receptor is dependent upon sodium ions. [PDF]

Sci Rep, 2018
Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.   +13 more
europepmc   +1 more source

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder. [PDF]

ACS Med Chem Lett, 2018
Marcin LR, Warrier J, Thangathirupathy S, Shi J, Karageorge GN, Pearce BC, Ng A, Park H, Kempson J, Li J, Zhang H, Mathur A, Reddy AB, Nagaraju G, Tonukunuru G, Gupta GVRKM, Kamble M, Mannoori R, Cheruku S, Jogi S, Gulia J, Bastia T, Sanmathi C, Aher J, Kallem R, Srikumar BN, Vijaya KK, Naidu PS, Paschapur M, Kalidindi N, Vikramadithyan R, Ramarao M, Denton R, Molski T, Shields E, Subramanian M, Zhuo X, Nophsker M, Simmermacher J, Sinz M, Albright C, Bristow LJ, Islam I, Bronson JJ, Olson RE, King D, Thompson LA, Macor JE.   +47 more
europepmc   +1 more source

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D₂ receptor. [PDF]

Biochem Pharmacol, 2018
Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.   +12 more
europepmc   +1 more source

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. [PDF]

Br J Pharmacol, 2015
Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM.   +3 more
europepmc   +1 more source

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K_Ca 2) channels. [PDF]

Br J Pharmacol, 2017
Simó-Vicens R, Kirchhoff JE, Dolce B, Abildgaard L, Speerschneider T, Sørensen US, Grunnet M, Diness JG, Bentzen BH.   +8 more
europepmc   +1 more source

Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients. [PDF]

Clin Transl Sci, 2018
Cosson V, Schaedeli-Stark F, Arab-Alameddine M, Chavanne C, Guerini E, Derks M, Mallalieu NL.   +6 more
europepmc   +1 more source

Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptors

Allum E, Stokes L.
europepmc   +1 more source

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Structure–Activity Relationships for Negative Allosteric mGluR5 Modulators

ChemMedChem, 2012
AbstractA series of compounds based on the mGluR5‐selective ligand 2‐methyl‐6‐(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to be either structural analogues of MPEP, substituted monomers, or dimeric analogues. All compounds retained mGluR5 selectivity with only weak or no activity at other mGluRs or iGluRs. The
Kaae, Birgitte H, Harpsøe, Kasper, Kvist, Trine, Mathiesen, Jesper M, Mølck, Christina, Gloriam, David E, Jimenez, Hermogenes N, Uberti, Michelle A, Nielsen, Søren M, Nielsen, Birgitte, Bräuner-Osborne, Hans, Sauerberg, Per, Clausen, Rasmus Prætorius, Madsen, Ulf   +13 more
openaire   +3 more sources