Results 71 to 80 of about 13,221 (154)

Identification of a β-arrestin-biased negative allosteric modulator for the β₂-adrenergic receptor. [PDF]

Proc Natl Acad Sci U S A, 2023
Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL.   +19 more
europepmc   +1 more source

Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. [PDF]

ACS Med Chem Lett, 2023
Rudd MT, Manley PJ, Hanney B, Meng Z, Shu Y, de Leon P, Frie JL, Han Y, Wai JM, Yang ZQ, Perkins JJ, Hurzy DM, Manikowski JJ, Zhu H, Bungard CJ, Converso A, Meissner RS, Cosden ML, Hayashi I, Ma L, O'Brien J, Uebele VN, Schachter JB, Bhandari N, Ward GJ, Fillgrove KL, Lu B, Liang Y, Dubost DC, Puri V, Eddins DM, Vardigan JD, Drolet RE, Kern JT, Uslaner JM.   +34 more
europepmc   +1 more source

Novel RXFP3 negative allosteric modulator RLX-33 reduces alcohol self-administration in rats. [PDF]

J Neurochem, 2023
Van Voorhies KJ, Liu W, Lovelock DF, Lin S, Liu J, Guan D, Gay EA, Jin C, Besheer J.   +8 more
europepmc   +1 more source

Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor. [PDF]

ACS Chem Neurosci, 2023
D'Erasmo MP, Akins NS, Ma P, Jing Y, Swanger SA, Sharma SK, Bartsch PW, Menaldino DS, Arcoria PJ, Bui TT, Pons-Bennaceur A, Le P, Allen JP, Ullman EZ, Nocilla KA, Zhang J, Perszyk RE, Kim S, Acker TM, Taz A, Burton SL, Coe K, Fritzemeier RG, Burnashev N, Yuan H, Liotta DC, Traynelis SF.   +26 more
europepmc   +1 more source

Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype [PDF]

ACS Medicinal Chemistry Letters, 2013
openaire   +2 more sources

Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease. [PDF]

Cells, 2023
Epping-Jordan MP, Girard F, Bessis AS, Mutel V, Boléa C, Derouet F, Bessif A, Mingard B, Barbier S, Paradis JS, Rocher JP, Lütjens R, Kalinichev M, Poli S.   +13 more
europepmc   +1 more source

The Antiseizure Drug Perampanel Is a Subunit-Selective Negative Allosteric Modulator of Kainate Receptors. [PDF]

J Neurosci, 2022
Taniguchi S, Stolz JR, Swanson GT.
europepmc   +1 more source

Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition. [PDF]

Neuropharmacology, 2023
Nuwer JL, Povysheva N, Jacob TC.
europepmc   +1 more source

Changes in social, sexual, and hedonic behaviors in rats in response to stress and restoration by a negative allosteric modulator of α5-subunit containing GABA receptor. [PDF]

Behav Brain Res, 2023
Bailey AM, Barrett A, Havens L, Leyder E, Merchant T, Starnes H, Thompson SM.   +6 more
europepmc   +1 more source

The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice

Neurobiology of Disease
Over the last few decades, scientists' attention has shifted from neuronal to non-neuronal cells to explain the mechanisms at the basis of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Matilde Balbi, Carola Torazza, Tiziana Altosole, Silvia Ravera, Emanuele Farinini, Sara Tessitore, Francesca Bacchetti, Francesca Rosso, Ilaria Musante, Silvana Alfei, Maria Cerminara, Aldamaria Puliti, Gilberto Filaci, Daniela Fenoglio, Riccardo Leardi, Ernesto Fedele, Giambattista Bonanno, Marco Milanese, Tiziana Bonifacino   +18 more
doaj   +1 more source