Results 71 to 80 of about 16,232 (241)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Negative concord in Washo as negative agreement
Proceedings of the Linguistic Society of America, 2019 Washo, a Native American isolate, displays negative concord morphology in the context of negation. Negative concord in Washo comes in the form of the morpheme -Na, which may be suffixed onto optionally many sentential elements in a single clause. Given the apparent lack of semantic contribution by this morpheme, I argue - building on accounts along the
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Historika : Studi di Storia Greca e Romana, 2016 Concord is order, harmony, balance, it is a moral principle that inspires pacific coexistence within the civic community; this is the image delivered by IV century philosophical and political thought. Such a notion was developed within a speculation over
Giovanna Daverio Rocchi
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
, 2019 <div> <p>In this article I will describe the general properties of Negative Concord in Russian, which is a strict Negative Concord language, where all negative indefinites must co-occur with sentential negation. However, there are several cases where the negation marker can be absent (like in fragment answers) or can appear in a non ...
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Linguistik Online, 2019 The article gives an overview of the form and function of negative concord in German dialects (Alemannic, Bavarian, Upper Franconian varieties, West Central German, East Central German, West Low German, East Low German, Silesian, East Pomeranian, Low ...
Ann-Marie Moser
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Overriding negative concord [PDF]
, 2010 Contains fulltext : 85884.pdf (Publisher’s version ) (Open Access)
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