Results 71 to 80 of about 91,665 (284)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Manchester Snow Emergency Analysis: Who is Being Towed from Where and Why [PDF]
, 2015 This Capstone paper analyzes the City of Manchester, New Hampshire’s policy and community impacts when their Towing Snow Emergency procedures are implemented.
Pelletier, Michael James
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Stellenbosch Papers in Linguistics Plus, 2015 This article has three major objectives. Firstly, it aims to describe and account for the peculiarity of the modern Afrikaans negative concord marker nie2 in the familiar Western European context.
Biberauer, Theresa
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Negative Dependencies in Turkish
LanguagesIn this paper, we provide an overview of negative dependencies in Turkish. The first are elements such as hiçkimse, which sometimes seem to mean ‘anybody’ and sometimes ‘nobody’.
Beste Kamali, Hedde Zeijlstra
doaj +1 more source
Generalized Pseudolikelihood Methods for Inverse Covariance Estimation [PDF]
, 2016 We introduce PseudoNet, a new pseudolikelihood-based estimator of the inverse covariance matrix, that has a number of useful statistical and computational properties.
Ali, Alnur +3 more
core +2 more sources
Language sample analysis for Spanish speakers [PDF]
, 2015 textThe purpose of this project was to develop a Spanish language sample analysis (LSA) scoring procedure for English-Spanish bilinguals used to guide clinicians in developing language goals and monitoring progress on those goals. A Spanish LSA procedure
Pool, Molly Lauren
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source