Results 51 to 60 of about 5,295,174 (295)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The feedback 's effect on motor learning task in pianists [PDF]

, 2023
openla presente tesi vuole investigare gli effetti di feedback positivi o negativi sull'apprendimento motorio in pianisti, con l'ipotesi che i pianisti mostreranno un apprendimento più veloce con feedback negativi.
TAGLIAVINI, CATERINA
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Molecular Systems Biology, 2014
The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback, and ...
Shoeb Ahmed, Kyle G Grant, Laura E Edwards, Anisur Rahman, Murat Cirit, Michael B Goshe, Jason M Haugh   +6 more
doaj   +1 more source

Feedback Stability of Negative Imaginary Systems [PDF]

IEEE Transactions on Automatic Control, 2017
This paper extends the robust feedback stability theorem of negative imaginary systems by removing restrictive assumptions on the instantaneous gains of the systems that were imposed in the earlier literature, and it further generalises this robust analysis result into the case that allows negative imaginary systems to have poles at the origin.
Alexander Lanzon, Hsueh-Ju Chen
openaire   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Executive dynamic scheduling algorithm based on high-order heterogeneity

Tongxin xuebao, 2022
At present, most isomer scheduling models in DHR systems only considered second-order isomerism and lack dynamics.In order to solve these problems, a dynamic scheduling algorithm was proposed, which combined heterogeneity and dynamics by determining a ...
Hongyong JIA, Yunfei PAN, Wenhe LIU, Junjie ZENG, Jianhui ZHANG   +4 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

NEGATIVE FEEDBACKS IN THE ECONOMY AND INDUSTRIAL LOCATION* [PDF]

Journal of Regional Science, 1996
ABSTRACT. Incorporating regional asymmetry and negative feedbacks (congestion) in a model of economic geography and international trade shows that complete specialization of production at one location is unlikely. We identify an agglomerating force: the home market effect, and two spreading forces, competition for demand from immobile sectors of ...
BRAKMAN, S., GARRETSEN, H., GIGENGACK, R., VANMARREWIJK, C., WAGENVOORT, Rien J.L.M.   +4 more
openaire   +5 more sources