Results 71 to 80 of about 702,888 (304)

Facing Cold-Start: A Live TV Recommender System Based on Neural Networks

IEEE Access, 2020
With the increase in the number of live TV channels, audiences must spend increasing amounts of time and energy deciding which shows to watch; this problem is called information overload, and recommender systems (RSs) are effective methods for addressing
Xiaosong Zhu, Jingfeng Guo, Shuang Li, Tong Hao   +3 more
doaj   +1 more source

Strong Coupling Between Carbon Cycle, Climate, and Weathering During the Paleocene‐Eocene Thermal Maximum

Geophysical Research Letters, 2023
The Paleocene‐Eocene Thermal Maximum (PETM; ∼56 Ma)–a geologically rapid carbon‐release event similar to anthropogenic carbon emissions–is ideal for investigating weathering responses to rapid carbon release and associated climate change.
Zuoling Chen, Zhongli Ding, Shiling Yang, Jimin Sun, Min Zhu, Yilin Xiao, Fengtai Tong, Yao Liang   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

negative feedback [PDF]

, 2019
Citation: 'negative feedback' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.N04097 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback [PDF]

, 2009
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply
Brazma Alvis, Klier, S, Codlin, S, Lackner Daniel H., Bahler, J, Alvis Brazma, Brian T Wilhelm, Robertus A M de Bruin, Sofia Aligianni, de Bruin, RAM, Daniel H Lackner, Sandra Codlin, Gabriella Rustici, Klier Steffi, Wilhelm, BT, Rustici Gabriella, Lackner, DH, Marguerat Samuel, Aligianni, S, Bähler Jürg, de Bruin, RA, Jürg Bähler, Brazma, A, Codlin Sandra, Marguerat, S, Steffi Klier, Wilhelm Brian T., Samuel Marguerat, Aligianni Sofia, de Bruin Robertus A. M., Rustici, G   +30 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Development of Low-noise Preamplifier for Low-field NMR

Chinese Journal of Magnetic Resonance
Nuclear magnetic resonance (NMR) technology enables the acquisition of multi-scale molecular dynamics by characterizing the variation of relaxation times under different magnetic field conditions, thereby offering a critical detection methodology for ...
LI Keyan, CHENG Xin, CHEN Junfei, CAO Li, HUANG Zhen, LIU Chaoyang   +5 more
doaj   +1 more source

Aprendendo com feedback: um estudo sobre como o cérebro utiliza informação para aprender [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em Psicologia.Para aprender, é necessário extrair e integrar informações de diferentes fontes.
Luft, Caroline Di Bernardi
core  

The fidelity of dynamic signaling by noisy biomolecular networks [PDF]

, 2013
Cells live in changing, dynamic environments. To understand cellular decision-making, we must therefore understand how fluctuating inputs are processed by noisy biomolecular networks.
Voliotis Margaritis, Margaritis Voliotis, Margaritis Voliotis (395876), Bowsher, CG, Bowsher Clive G., Peter S Swain, Swain, Peter S, Clive G Bowsher, Peter S. Swain, Bowsher, Clive G., Voliotis, Margaritis, Clive G. Bowsher (395875), Bowsher, Clive G, Clive G. Bowsher, Peter S. Swain (238162), Voliotis, M, Swain, Peter S., Swain, PS, Swain Peter S.   +18 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source