Results 71 to 80 of about 5,295,174 (295)

Strong Coupling Between Carbon Cycle, Climate, and Weathering During the Paleocene‐Eocene Thermal Maximum

Geophysical Research Letters, 2023
The Paleocene‐Eocene Thermal Maximum (PETM; ∼56 Ma)–a geologically rapid carbon‐release event similar to anthropogenic carbon emissions–is ideal for investigating weathering responses to rapid carbon release and associated climate change.
Zuoling Chen, Zhongli Ding, Shiling Yang, Jimin Sun, Min Zhu, Yilin Xiao, Fengtai Tong, Yao Liang   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Development of Low-noise Preamplifier for Low-field NMR

Chinese Journal of Magnetic Resonance
Nuclear magnetic resonance (NMR) technology enables the acquisition of multi-scale molecular dynamics by characterizing the variation of relaxation times under different magnetic field conditions, thereby offering a critical detection methodology for ...
LI Keyan, CHENG Xin, CHEN Junfei, CAO Li, HUANG Zhen, LIU Chaoyang   +5 more
doaj   +1 more source

Evolutionary Selection of Expectations in Positive and Negative Feedback Markets [PDF]

An economic environment is a feedback system, where dynamics of aggregate variables depend on individual expectations and also shape them. The type of feedback mechanism is crucial for the aggregate outcome.
Philipse, R., Hommes, C.H., Anufriev, M.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Dynamics of a state-dependent delay-differential equation

Electronic Journal of Qualitative Theory of Differential Equations
We present a detailed study of a scalar differential equation with threshold state-dependent delayed feedback. This equation arises as a simplification of a gene regulatory model.
Tomas Gedeon, Antony Humphries, Michael Mackey, Hans-Otto Walther, Zhao Wang   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

How leaders can use negative feedback to their advantage.

, 2017
This short article explores how leaders can use negative feedback to their advantage by identifying their weaknesses andturning them into strengths. In order to enable their peers to give them true feedback, leaders should nurture a safeenvironment of ...
Papasava, Angeliki
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source