Results 61 to 70 of about 1,617,958 (348)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Analysis and optimization of cesium dynamics for the HUST negative ion source

Nuclear Engineering and Technology
The high-density beam in the NBI negative ion source relies on surface production on the converter with low work function, which is facilitated by cesium injection.
Feng Xue, Chen Zuo, Dong Li, Dezhi Chen
doaj   +1 more source

Negative ion research at the Culham Centre for Fusion Energy (CCFE)

New Journal of Physics, 2016
A summary of negative ion development work being presently undertaken at the Culham Centre for Fusion Energy is given. The small negative ion facility has an RF driven volume ion source with beam extraction at energies up to 30 keV. The extracted beam of
R McAdams, A J T Holmes, D B King, E Surrey, I Turner, J Zacks   +5 more
doaj   +1 more source

Negative ion source development for a photoneutralization based neutral beam system for future fusion reactors

, 2016
In parallel to the developments dedicated to the ITER neutral beam (NB) system, CEA-IRFM with laboratories in France and Switzerland are studying the feasibility of a new generation of NB system able to provide heating and current drive for the future ...
A. Simonin, R. Agnello, S. Béchu, J. Bernard, C. Blondel, J. Boeuf, D. Bresteau, G. Cartry, W. Chaibi, C. Drag, B. Duval, H. D. Esch, G. Fubiani, I. Furno, C. Grand, P. Guittienne, A. Howling, R. Jacquier, C. Marini, I. Morgal   +19 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Helicon wave-generated plasmas for negative ion beams for fusion

EPJ Web of Conferences, 2017
In the next generation of fusion reactors, such as DEMO, neutral beam injectors (NBIs) of high energy (0.8-1 MeV) deuterium atoms with high wall-plug efficiency (>50%) will be required to reach burning plasma conditions and to provide a significant ...
Furno Ivo, Agnello Riccardo, Fantz U., Howling Alan, Jacquier Remy, Marini Claudio, Plyushchev Gennady, Guittienne Philippe, Simonin Alain   +8 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ITER-relevant 600 s steady-state extraction of negative hydrogen ions at the test facility ELISE

Nuclear Fusion
The neutral beam heating system for the future international fusion experiment ITER will be based on radio-frequency driven ion sources delivering a large (≈1 × 2 m ^2 ) and homogeneous negative hydrogen or deuterium ion beam of several ten Amperes for ...
D. Wünderlich, R. Riedl, M. Fröschle, A. Heiler, A. Navarro, D. Yordanov, A. Döring, U. Fantz   +7 more
doaj   +1 more source

Hard photon flow and photon-photon correlation in intermediate energy heavy-ion collisions

, 2012
Hard photons emitted from energetic heavy ion collisions are very interesting since they do not experience nuclear interaction, and therefore they are useful to explore properties of nuclear matter.
D. Q. Fang, G. H. Liu, H. W. Wang, J. D. Jackson, J. Łukasik, R. Hanbury-Brown, W. D. Tian, W. Guo, W. Q. Shen, X. Z. Cai, Y. G. Ma   +10 more
core   +1 more source

Start of SPIDER operation towards ITER neutral beams [PDF]

, 2018
Heating Neutral Beam (HNB) Injectors will constitute the main plasma heating and current drive tool both in ITER and JT60-SA, which are the next major experimental steps for demonstrating nuclear fusion as viable energy source.
Agostinetti, P., Agostini, M., Antoni, V., Aprile, D., Baltador, C., Barbisan, M., Battistella, M., Bello, S. Dal, Bigi, M., Boilson, D., Boldrin, M., Bonicelli, T., Brombin, M., Cavazzana, R., Cavenago, M., Chakraborty, A., Chitarin, G., Dan, M., De Lorenzi, A., De Muri, M., Delogu, R., Denizeau, S., Fadone, M., Fantz, U., Fellin, F., Ferbel, L., Ferro, A., Gaio, E., Gambetta, G., Gasparini, F., Gnesotto, F., Grando, L., Heinemann, B., Jain, P., Kraus, W., Luchetta, A., Maistrello, A., Manduchi, G., Manfrin, S., Marchiori, G., Marconato, N., Marcuzzi, D., Moresco, M., Palma, M. Dalla, Pasqualotto, R., Patel, H., Patton, T., Pavei, M., Peruzzo, S., Pilan, N., Pimazzoni, A., Piovan, R., Poggi, C., Pomaro, N., Recchia, M., Rizzolo, A., Rostagni, G., Rotti, C., Sartori, E., Serianni, G., Singh, N. P., Siragusa, M., Sonato, P., Spagnolo, S., Spolaore, M., Taliercio, C., Tinti, P., Toigo, V., Ugoletti, M., Valente, M., Veltri, P., Zaccaria, P., Zamengo, A., Zaniol, B., Zanotto, L., Zaupa, M.   +75 more
core   +1 more source