Results 71 to 80 of about 1,131,290 (276)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ionic diffusion into the peripheral area of a glow discharge in the electronegative gases

St. Petersburg Polytechnical University Journal: Physics and Mathematics
In the paper, the effect of negative ion diffusive penetration from the central space representing the ion-ion plasma on the electron-ion plasma located in the peripheral area of a positive column of a glow discharge in the strong electronegative gases ...
Golovitskii Alexander
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Instrumentation for Negative Ion Detection [PDF]

Environmental Health Perspectives, 1980
The instrumentation and practical circuitry required for the detection of negative ions exiting the mass analysis section of a mass spectrometer is examined. The potentials needed to bias the electron multiplier when detecting negative ions from a low ion-energy mass spectrometer, e.g., a quadrupole, are contrasted with the biasing requirements of a ...
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Envelope excitations in electronegative plasmas with electrons featuring the Tsallis distribution

, 2013
We examine the modulational instability (MI) of ion-acoustic waves (IAWs) in an electronegative plasma containing positive and negative ions as well as electrons that follow the nonextensive statistics proposed by Tsallis [J. Stat. Phys. 52, 479 (1988)].
Bains, A. S., Li, B., Tribeche, Mouloud
core   +1 more source

High-intensity negative ion sources [PDF]

Nuclear Instruments and Methods, 1963
The production of beams of negative deuterium ions was studied with two ion sources with geometries that could be employed in a cyclotron. The negative ions were extracted directly from the arc in a direction normal to the magnetic field without using a charge-exohange medium. With a high gas pressure in the arc and an arc current of 5 amp, a 2-ma beam
Ehlers, Kenneth W., Gavin, Basil P., Hubbard, Edward L.   +2 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Generation of hydrogen ionic plasma superimposed with positive ion beam

AIP Advances, 2019
In this study, a hydrogen ionic plasma with relatively low residual fractional electron concentration (ne/n+ ∼ 10−2) is generated using an aluminum plasma grid for the production of negative hydrogen ions and a control grid for negative ion extraction ...
W. Oohara, M. Fujii, M. Watai, Y. Hiraoka, M. Egawa, Y. Morinaga, S. Takamori, M. Yoshida   +7 more
doaj   +1 more source

Extraction and low energy transport of negative ions [PDF]

, 2005
High perveance negative ion beams with low emittance are essential for several next generation particle accelerators (i. g. spallation sources like ESS [1] and SNS [2]).
Jakob, Ansgar, Klein, Horst, Lakatos, Andreas, Pozimski, Jürgen   +3 more
core