Results 91 to 100 of about 3,708,738 (393)

Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions [PDF]

, 2012
Background There are currently no reliable markers of acute domoic acid toxicosis (DAT) for California sea lions. We investigated whether patterns of serum peptides could diagnose acute DAT.
Almeida, Jonas S, Carlin, Kevin P, Favre, Elizabeth G, Greig, Denise J, Gulland, Frances MD, Janech, Michael G, Neely, Benjamin A, Soper, Jennifer L   +7 more
core   +3 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

The role of endoscopic ultrasound-guided fine-needle aspiration/biopsy in the diagnosis of mediastinal lesions

Frontiers in Surgery, 2023
ObjectiveEndoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) is an accurate technique for sampling the pancreas and mediastinum. The aim of this study was to determine the value of EUS-FNA/FNB in the diagnosis of mediastinal lesions ...
Jingjing Zhou, Jingjing Zhou, Ting Cai, Ting Cai, Dongwen Wu, Dongwen Wu, Xiong Chen, Xiong Chen, Fen Wang, Fen Wang   +9 more
doaj   +1 more source

Treat Different Negatives Differently: Enriching Loss Functions with Domain and Range Constraints for Link Prediction [PDF]

arXiv, 2023
Knowledge graph embedding models (KGEMs) are used for various tasks related to knowledge graphs (KGs), including link prediction. They are trained with loss functions that consider batches of true and false triples. However, different kinds of false triples exist and recent works suggest that they should not be valued equally, leading to specific ...
arxiv  

Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria. [PDF]

, 2001
In view of the recent discovery (Molecular Cell 6, 861-871) of a (Lys76Thr) codon change in gene pfcrt on chromosome 7 which determines in vitro chloroquine resistance in Plasmodium falciparum, we have re-examined samples taken before treatment in our ...
Boko, Pelagie, Dadzie, Samuel, Djogbenou, Luc, Donnelly, Martin, Dowd, Andrew, Jenkins, Adam M., Lu, Fang, Mayans, Olga, Mitchell, Sara N., Muskavitch, Marc A. T., Paine, Mark, Ranson, Hilary, Regna, Kimberly, Rigden, Daniel J., Weetman, David, Wilding, Craig S.   +15 more
core   +5 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Transcriptome Analysis of Triple-Negative Breast Cancer Reveals an Integrated mRNA-lncRNA Signature with Predictive and Prognostic Value.

Cancer Research, 2016
While recognized as a generally aggressive disease, triple-negative breast cancer (TNBC) is highly diverse in different patients with variable outcomes.
Yizhou Jiang, Yirong Liu, Xiao-En Xu, Xi Jin, Xin Hu, Keda Yu, Z. Shao   +6 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The importance of a patient’s background in formulating a management approach

Healthcare in Low-resource Settings, 2013
Peptic ulcer disease is uncommon in childhood, with non-specific clinical features. A tendency to late diagnosis makes it more likely for a patient to present with complications.
Anil Ojha, Pawan Shrestha, David A. Green   +2 more
doaj   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source