Results 121 to 130 of about 1,591,983 (307)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Not All Patients Need a CT When the Appendix Is Not Seen on Ultrasound: A Scoping Review

Diagnostics
Background/Objective: Recent North American guidelines suggest that CT is indicated for further evaluation where ultrasound (US) is negative, although the negative predictive value (NPV) of ultrasound in adult patients when the appendix is not seen ...
Ali Ramji, Justin J. Y. Kim, Gavin Low, Karim Samji, Mitchell P. Wilson   +4 more
doaj   +1 more source

Negative Predictive Value of Circulating Tumor Tissue Modified Viral (TTMV)-HPV DNA for HPV-driven Oropharyngeal Cancer Surveillance. [PDF]

Clin Cancer Res, 2023
Hanna GJ, Roof SA, Jabalee J, Rettig EM, Ferrandino R, Chen S, Posner MR, Misiukiewicz KJ, Genden EM, Chai RL, Sims J, Thrash E, Stern SJ, Kalman NS, Yarlagadda S, Raben A, Clements L, Mendelsohn A, Kaczmar JM, Pandey Y, Bhayani M, Gupta P, Kuperwasser C, Del Vecchio Fitz C, Berger BM.   +24 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Effect of Alvarado Score on the Negative Predictive Value of Nondiagnostic Ultrasound for Acute Appendicitis. [PDF]

J Med Ultrasound, 2022
Prapruttam D, Klawandee S, Tangkittithaworn P, Wongwaisayawan S.   +3 more
europepmc   +1 more source

Automated Identification of Unhealthy Drinking Using Routinely Collected Data: A Machine Learning Approach [PDF]

, 2019
Background: Unhealthy drinking is prevalent in the United States and can lead to serious health and social consequences, yet it is under-diagnosed and under-treated. Identifying unhealthy drinkers can be time-consuming for primary care providers.
Bonnell, Levi N., Littenberg, Benjamin, Rose, Gail L., Wshah, Safwan R.   +3 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patients. [PDF]

J Infect, 2022
Carbonell R, Urgelés S, Salgado M, Rodríguez A, Reyes LF, Fuentes YV, Serrano CC, Caceres EL, Bodí M, Martín-Loeches I, Solé-Violán J, Díaz E, Gómez J, Trefler S, Vallverdú M, Murcia J, Albaya A, Loza A, Socias L, Ballesteros JC, Papiol E, Viña L, Sancho S, Nieto M, Del M, Lorente C, Badallo O, Fraile V, Arméstar F, Estella A, Abanses P, Sancho I, Guasch N, Moreno G, COVID-19 SEMICYUC Working Group and the LIVEN-Covid-19 Investigators.   +34 more
europepmc   +1 more source

The Value of Bacterial Culture During Clean Orthopedic Surgery a Prospective Study of 1,036 Patients [PDF]

, 2017
Objective: To determine whether bacterial cultures of the wounds of patients undergoing clean orthopedic surgery would help predict infection. Methods: During 1 year, 1,256 cultures were performed for 1,102 patients who underwent clean orthopedic surgery.
Bernard, Louis, Hoffmeyer, Pierre, Lew, Daniel, Monin, Daniel, Rohner, Peter, Sadowski, Christophe, Stern, Richard, Wyssa, Blaise   +7 more
core