Results 51 to 60 of about 165,790 (343)

Cost-effectiveness analysis alongside a pilot study of prophylactic negative pressure wound therapy [PDF]

, 2016
Background Negative pressure wound therapy (NPWT) is increasingly used prophylactically following surgery despite limited evidence of clinical or cost-effectiveness.
Andersson, Banwell, Brazier, Briggs, Chaboyer, de Leon, Drummond, Echebiri, Eichler, Fry, Glick, Gregor, Manca, Mangram, Mark, Neubauer, Othman, Peinemann, Phillips, Queensland Health, Ramachenderan, Soares, Soares, Stannard, Ubbink, Urban, Webster   +26 more
core   +1 more source

Diabetes mellitus and necrotizing fasciitis – a deadly combination; case report [PDF]

, 2020
Necrotizing fasciitis is a rapidly destructive affliction of soft tissues, with a mortality rate that may reach 73% of the cases. It is characterized by a progressive inflammation and extended necrosis of the subcutaneous tissue and the fascia ...
Andronache, Liliana Florina, Bica, Cristina, Gherghiceanu, Florentina, Mazilu, Laura, Moroianu, Lavinia Alexandra, Paunica, Ioana, Sandu, Camelia, Suceveanu, Andra Iulia, Toma, Alexandra   +8 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evidence update on prevention of surgical site infection [PDF]

, 2015
Purpose of review: surgical site infection (SSI) is a common health care associated infection and complicates up to 10-20% of operations with considerable health care resources.
Astagneau, Bayat, Blackham, Bonds, Bunn, Cabaluna, Daoud, Darouiche, Edmiston, Fry, Gheorghe, Grauhan, Jakobsson, Kamel, Kent, Kirby, Krieger, Leaper, Leaper, Leaper, Leaper, Leaper, Leaper, Lyytikainen, Matatov, Melling, Pauli, Pinkney, Richet, Sanchez-Manuel, Stannard, Strecker, Tanner, Tanner, Taylor, Thibon, Togioka, Turtiainen, Ubbink, Wang, Webster, Williams, Yokoe   +42 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The Efficacy of Pressure Ulcer Treatment With Cathodal and Cathodal-Anodal High-Voltage Monophasic Pulsed Current: A Prospective, Randomized, Controlled Clinical Trial [PDF]

, 2017
Background. Studies show that anode and cathode electrical stimulation (ES) promotes the healing of wounds, but specific protocols for both electrodes are not available. Objective. To compare the effectiveness of cathodal versus cathodal+anodal ES in the
Blaszczak, Edward, Franek, Andrzej, Hordynska, Ewa, Ickowicz, Tomasz, Kloth, Luther C., Kucio, Cezary, Nawrat-Szoltysik, Agnieszka, Polak, Anna, Taradaj, Jakub   +8 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

NEGATIVE PRESSURE WOUND THERAPY (NPWT) FOR THE MANAGEMENT OF DIABETIC FOOT WOUND

Jurnal Ilmiah Kesehatan, 2015
Complications often experienced by people with diabetes are complications in the feet ( 15 % ) called diabetic foot ( Akhtyo , 2009) . Where the injury to the leg if not treated properly will lead to infections and ultimately need to be amputated .The ...
Wesiana Heris Santy
doaj   +3 more sources

Advances in the treatment of combat trauma to the extremities: photodynamic therapy and methods of plastic wound closure

Український журнал клінічної хірургії, 2023
Objective. To evaluate our own ten–year experience in the use of photodynamic therapy and plastic wound closure methods in the treatment of combat trauma victims using various photosensitizers and light sources, as well as tissue therapy.
Yu.V. Ivanova, S. M. Gramatyuk, I. A. Kryvoruchko, V. O. Prasol, K. V. Myasoedov   +4 more
doaj   +1 more source

Major cardiac rupture following surgical treatment for deep sternal wound infection. [PDF]

, 2013
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Geirsson, Arnar, Gudbjartsson, Tomas, Thorsteinsson, David T, Valsson, Felix   +3 more
core   +1 more source