Results 71 to 80 of about 8,358,165 (249)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Feasibility of a disposable canister-free negative-pressure wound therapy (NPWT) device for treating open wounds in horses

BMC Veterinary Research, 2019
Background Wounds are among the most common medical conditions affecting horses and have a major economic impact on the horse industry. Wound healing in horses is distinct to that documented in other species, and often results in delayed healing and ...
Louis Kamus, Marie Rameau, Christine Theoret   +2 more
doaj   +1 more source

A simple and low- cost technique for Closed Incision Negative-Pressure Therapy [PDF]

, 2017
Surgical site infection (SSI) makes patient care more expensive by prolonging antibiotic usage and hospital stay. Negative pressure wound therapy (NPWT) has been recently reported as a preventive strategy to avoid SSI.
Michał Wojtyniak, Zbigniew Pasieka, Dominik Andrzej Walczak, Pawełczak, Dariusz, Wojtyniak, Michał, Trzeciak, Piotr Wojciech, Pasieka, Zbigniew, Dariusz Pawełczak, Walczak, Dominik Andrzej, Piotr Wojciech Trzeciak   +9 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Prospective Assessment of the Negative Pressure Wound Therapy of the Open Abdomen [PDF]

, 2016
Open abdomen (OA) is a surgical approach, that emerged in last 15 years, with its management being complicated, timely and financially demanding, burdened with high morbidity and mortality.
Hutan, Martin, Skultety, Jan, Sekac, Jaroslav, Kutarna, Juraj, Loncsar, Gerhard, Prochotsky, Augustin, Bartko, Christian   +6 more
core   +1 more source

Comparison of Negative Pressure Wound Therapy Versus Conventional Wound Care in the Treatment of Mesh Infection Following Incisional Hernia Repair

Medicine Science
Postoperative incisional hernias are common complications following abdominal surgeries, necessitating timely repair to mitigate the risk of incarceration.
Husnu Cagri Genc, Hakki Coskun
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A simple and low-cost technique of creating a Negative Pressure Wound Therapy (NPWT) machine on the example of a severe phlegmon of lower limb in lower socio-economic area. [PDF]

, 2018
The Negative Pressure Wound Therapy (NPWT) is an approved method of healing lower extremity ulcers of various origin, accelerating the wound closure process, thus decreasing the hospital-stay time and lowering the cost of the treatment.
Kazubski, Filip, Kiszka, Marcin, Banasiewicz, Tomasz, Maj, Magdalena   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The Importance of Hydration in Wound Healing: Reinvigorating the clinical perspective [PDF]

, 2016
Balancing skin hydration levels is important as any disruption in skin integrity will result in disturbance of the dermal water balance. The discovery that a moist wound healing environment actively supports the healing response when compared to a dry ...
Cutting, K. F., Ousey, K., Rogers, A. A., Cutting, Keith, Rippon, Mark, Rippon, Mark G., Rogers, Alan A., Ousey, Karen   +7 more
core   +1 more source