Results 71 to 80 of about 66,443 (291)

An Affordable Custom-Built Negative Pressure Wound Therapy

The Annals of African Surgery, 2017
Negative pressure wound therapy (NPWT) is a well-established and effective method for treating complex wounds. However, this modality of treatment may not be available in limited-resource countries due to the high cost.
Alshazaly Mohamed Abdal-Kareem Isaac, Mohamed Elamin Salim, Ihab Abdel-Rahim Mohamed Ahmed   +2 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Modern alternative or first-line treatment: How to safely use Negative Pressure Wound Therapy in Diabetic Foot Syndrome?

, 2015
Clinical experience and basic science studies show that Negative Pressure Wound Therapy (NPWT) is a promising yet still under-used treatment method for patients with diabetic foot syndrome (DFS).
Mrozikiewicz-Rakowska, Beata, Nowak, Adrianna, Kania, Joanna, Chojnowski, Marek, Bucior, Ewelina, Krzymień, Janusz   +5 more
core   +1 more source

Feasibility of a disposable canister-free negative-pressure wound therapy (NPWT) device for treating open wounds in horses

BMC Veterinary Research, 2019
Background Wounds are among the most common medical conditions affecting horses and have a major economic impact on the horse industry. Wound healing in horses is distinct to that documented in other species, and often results in delayed healing and ...
Louis Kamus, Marie Rameau, Christine Theoret   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Negative Pressure Wound Therapy for Necrotizing Fasciitis and Compartment Syndrome of the Upper Extremity — a case report

, 2019
Background: Necrotizing fasciitis (NF) is a lifethreateninginfection of the subcutaneous tissues that spreadsalong the underlying fascia. Despite the early and aggressivesurgical fasciotomy and necrectomy, its mortality rate is stillhigh.
Szentkereszty, Zsolt, Susán, Zsolt, Bazsó, Tamás, Mudriczki, Gábor, Győry, Ferenc, Enyedi, Attila, Damjanovich, László   +6 more
core   +1 more source

The Effect of Negative-Pressure Wound Therapy with Instillation Compared to Current Standard Care on Wound Closure Time of Infected Wounds: A Systematic Review and Meta-Analysis

, 2022
BACKGROUND: Infected wounds extend healing time and are associated with higher treatment costs than noninfected wounds. Several observational studies indicate that negative-pressure wound therapy with instillation can effectively reduce bacterial ...
Timmer, Allard S., Eskes, Anne M, Hompes, Roel, Zwanenburg, Pieter R, Boermeester, Marja A, Timmer, Allard S, Pieter R. Zwanenburg, Anne M. Eskes, Eskes, Anne M., Boermeester, Marja A., Allard S. Timmer, Marja A. Boermeester, Zwanenburg, Pieter R., Roel Hompes   +13 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A simple and low- cost technique for Closed Incision Negative-Pressure Therapy

, 2017
Surgical site infection (SSI) makes patient care more expensive by prolonging antibiotic usage and hospital stay. Negative pressure wound therapy (NPWT) has been recently reported as a preventive strategy to avoid SSI.
Michał Wojtyniak, Zbigniew Pasieka, Dominik Andrzej Walczak, Pawełczak, Dariusz, Wojtyniak, Michał, Trzeciak, Piotr Wojciech, Pasieka, Zbigniew, Dariusz Pawełczak, Walczak, Dominik Andrzej, Piotr Wojciech Trzeciak   +9 more
core   +1 more source