PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Bonding social capital, disaster experience, and post-disaster giving in Japan. [PDF]
Okubo T, Noy I.
europepmc +1 more source
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun +6 more
wiley +1 more source
Negative workplace gossip and organizational citizenship behavior in the Chinese kindergarten teaching workforce: exploring interpersonal trust as a mediator. [PDF]
Xu L, Feng B, Mao S.
europepmc +1 more source
Colossal Photovoltaic Current in Ferroelectric Oxide by Constructing Defect Band
Colossal photovoltaic current density of 34.36 mA/cm2 under 375 nm illumination has been achieved in the Pb‐deficient PbTiO3 film. The ultraviolet photoresponsivity surpasses that of all reported ferroelectric materials. This enhancement is attributed to the junction effect between the Pb‐deficient and non‐defective layers.
Yiran Sun +16 more
wiley +1 more source
Social capital's association with self-reported health outcomes in the rural south: variations by demographic subgroup. [PDF]
Bigger LM +5 more
europepmc +1 more source
How Machiavellian leadership affects employees' happiness at work: the role of psychological contract breach and coworker exchange. [PDF]
Wu H, Lu S, Liu A.
europepmc +1 more source
The 'active reciprocity' ecosystem: senior cohousing as a determinant of social support and cognitive vitality independent of socioeconomic status. [PDF]
Delgado-Losada ML +4 more
europepmc +1 more source
The role of trust and happiness in the relationship between organizational ostracism and turnover intentions among healthcare professionals: a serial mediation model. [PDF]
Kopuz K, Ozisli O, Ekmen E, Kocak O.
europepmc +1 more source
Reduced reliance on partner reciprocity drives lower trust in schizophrenia
Bellucci G +4 more
europepmc +1 more source

