Results 51 to 60 of about 26,569 (280)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prevention-focused self-regulation and aggressiveness [PDF]

open access: yes, 2008
The present research examined the relationship between individual differences in self-regulatory mechanisms as outlined in regulatory focus theory (promotion- and prevention-focused self-regulation) and aggressiveness.
Hurst, Melanie   +3 more
core   +1 more source

The relationship between moral sensitivity and prosocial behavior in college students: the mediating roles of moral disengagement and reciprocity norms

open access: yesFrontiers in Psychology
IntroductionThis study examined the relationship between moral sensitivity and prosocial behavior, as well as the mediating role of moral disengagement and reciprocity norms.MethodsTotally 567 college students completed Dispositional Moral Sensitivity ...
Zhiyong Li   +4 more
doaj   +1 more source

Interactive Effects of Workplace Ostracism and Belief in Reciprocity on Fear of Negative Evaluation [PDF]

open access: yesPakistan Journal of Commerce and Social Sciences, 2017
Workplace mistreatment is although one of crucial reality of organization’s life that exists inevitably but it may possess certain potential in collaboration with other variables to act into prosocial behaviors.
Qura-tul-aain Khair
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Short-Term Reciprocity in Macaque’s Social Decision-Making

open access: yesFrontiers in Behavioral Neuroscience, 2019
Primates live in complex social environments, where individuals create meaningful networks by adapting their behavior according to past experiences with others.
Sébastien Ballesta   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Neural correlate of human reciprocity in social interactions

open access: yesFrontiers in Neuroscience, 2013
Reciprocity plays a key role maintaining cooperation in society. However, little is known about the neural process that underpins human reciprocity during social interactions.
Shiro eSakaiya   +6 more
doaj   +1 more source

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