Results 71 to 80 of about 26,569 (280)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Reciprocity of thermal diffusion in time-modulated systems

open access: yesNature Communications, 2022
The use of time modulation to break reciprocity is well understood for light, sound or charge diffusion, but it’s unclear whether it can work for thermal diffusion.
Jiaxin Li   +10 more
doaj   +1 more source

Indirect reciprocity with negative assortment and limited information can promote cooperation [PDF]

open access: yesJournal of Theoretical Biology, 2018
Cooperation is ubiquitous in biological and social systems, even though cooperative behavior is often costly and at risk of exploitation by non-cooperators. Several studies have demonstrated that indirect reciprocity, whereby some members of a group observe the behaviors of their peers and use this information to discriminate against previously ...
Brush, E.   +2 more
openaire   +4 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Exploring the Influence of Workplace Ostracism on Knowledge Hiding: The Mediating Effect of Reciprocal Beliefs [PDF]

open access: yesنشریه مطالعات دانش‌پژوهی
Purpose: This study investigates the impact of workplace ostracism on knowledge hiding, emphasizing the mediating role of reciprocity beliefs among library staff at the University of Tehran.Methodology: This research is descriptive and survey-based, and ...
Seifallah Andayesh
doaj   +1 more source

Asymptotic Eulerian expansions for binomial and negative binomial reciprocals [PDF]

open access: yesProceedings of the American Mathematical Society, 1999
Asymptotic expansions of any order for expectations of inverses of random variables with positive binomial and negative binomial distributions are obtained in terms of the Eulerian polynomials. The paper extends and improves upon an expansion due to David and Johnson (1956-7).
Marciniak, Ewa, Wesolowski, Jacek
openaire   +2 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Emotional Feeding and Emotional Eating: Reciprocal Processes and the Influence of Negative Affectivity [PDF]

open access: yesChild Development, 2018
Abstract Emotional eating, that is, eating more in response to negative mood, is often seen in children. But the origins of emotional eating remain unclear. In a representative community sample of Norwegian 4-year-olds followed up at ages 6, 8, and 10 years (analysis sample: n = 801), one potential developmental pathway was examined ...
Steinsbekk, S   +4 more
openaire   +8 more sources

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

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