Results 241 to 250 of about 4,598,204 (290)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

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Negative selection of lymphocytes

Cell, 1994
Almost by definition, negative selection of T and B lymphocytes cannot be absolute. Given that both sets of receptors are derived by stochastic processes, recognition of epitopes by lymphocyte receptors will not be an all or none affair but a relative one.
openaire   +4 more sources

NR4A3 Mediates Thymic Negative Selection

The Journal of Immunology, 2021
Abstract Central tolerance aims to limit the production of T lymphocytes bearing TCR with high affinity for self-peptide presented by MHC molecules. The accumulation of thymocytes with such receptors is limited by negative selection or by diversion into alternative differentiation, including T regulatory cell commitment.
Salix Boulet, Livia Odagiu, Mengqi Dong, Marie-Ève Lebel, Jean-François Daudelin, Heather J Melichar, Nathalie Labrecque   +6 more
openaire   +2 more sources

Revisiting Negative Selection Algorithms

Evolutionary Computation, 2007
This paper reviews the progress of negative selection algorithms, an anomaly/change detection approach in Artificial Immune Systems (AIS). Following its initial model, we try to identify the fundamental characteristics of this family of algorithms and summarize their diversities.
Zhou, Ji, Dipankar, Dasgupta
openaire   +2 more sources

The Thymus and Negative Selection

Immunologic Research, 2000
Summary: Maintenance of tolerance to self antigens is presumed to reflect a combination of central and peripheral tolerance. For T cells, central tolerance occurs during early T cell development in the thymus and causes cells with strong reactivity to self antigens to be destroyed in situ (negative selection).
Jonathan, Sprent, Hidehiro, Kishimoto
openaire   +3 more sources

Progenitor Cells Purging: Negative Selection

The International Journal of Artificial Organs, 1993
Disease relapse after autologous bone marrow transplantation (ABMT) may arise from residual tumor in the recipient and/or from cancer cells that are reinfused. The aim of purging by negative selection is to remove tumor cells from the marrow without adversely affecting the engraftment potential of the normal cell.
L, De Rosa, A, Montuoro, A, Pandolfi, U, Paladini, T, Lanti, R, Morara, A, De Laurenzi   +6 more
openaire   +2 more sources

Positive and Negative Thymocyte Selection

Critical Reviews™ in Immunology, 1998
T cells differentiate from CD4-CD8- (DN) precursor to mature CD4+ or CD8+ (SP) thymocytes through the CD4+CD8+ (DP) stage. Immature thymocytes express pre-TCR complex composed of pT alpha and TCR beta chains, which plays a role in allelic exclusion of TCR beta and promotion from DN to DP transition.
T, Saito, N, Watanabe
openaire   +2 more sources

Negative selection and autoimmunity

Current Opinion in Immunology, 2003
The impaired elimination of self-reactive T cells is one factor that contributes to autoimmunity. Although the mechanism of thymic negative selection has been studied for decades, recent data demonstrate that the mechanisms underlying this fundamental process remain extremely controversial.
openaire   +2 more sources