Results 91 to 100 of about 12,015,384 (327)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Negative Selection Algorithm for DNA Sequence Classification

International Journal of Fuzzy Logic and Intelligent Systems, 2004
According to revealing the DNA sequence of human and living things, it increases that a demand on a new computational processing method which utilizes DNA sequence information. In this paper we propose a classification algorithm based on negative selection of the immune system to classify DNA patterns.
Dong Wook Lee, Kwee-Bo Sim
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Identification and location method of asymmetric faults in coal mine power network

Gong-kuang zidonghua, 2018
Three asymmetrical faults of singe-phase grounding, singe-phase line breakage and ferroresonance in coal mine power network are easily misjudged, and existing methods hardly identify the three faults correctly.
WANG Qingliang, QIN Jie, LIU Xinru
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Research on coordinated control method of hybrid energy storage systems connected traction power supply system based on PFTD

机车电传动
Electrified railways using single-phase power-frequency AC systems have the advantages of pollution-free operation and high transportation efficiency.
HUANG Jun
doaj  

SOME EXACT LIMIT THEOREMS FOR NEGATIVELY ASSOCIATED SEQUENCES

Kyushu Journal of Mathematics, 2013
Let \(\alpha ,\delta >0\) and \(L=\delta ^{-1}\operatorname{E}\left| N\right|^{\alpha \delta +2},\) where \(N\) stands for a standard normal random variable. Let also \(w_{n}=(\log \log n)^{\delta -1}/n^{2}\log n,\) \(n\geq 3\). Let \(X_{1},X_{2},\dots\) be a stationary sequence of negatively associated random variables with \(\operatorname{E}X_{1}=0\),
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Software-decoding Algorithm of Resolver Based on the Separation of Positive and Negative Sequence

Kongzhi Yu Xinxi Jishu, 2021
In order to eliminate the angle error caused by amplitude imbalance and phase non-orthogonality of resolver sine and cosine feedback signals, dq transform and positive and negative sequence separation are carried out to resolve sine and cosine feedback ...
GUO Zhida, CHEN Lei, ZHOU Cheng, CHEN Jianming, LIU Wang   +4 more
doaj