Results 61 to 70 of about 6,698,062 (304)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The impact of different negative training data on regulatory sequence predictions.
PLoS ONE, 2020 Regulatory regions, like promoters and enhancers, cover an estimated 5-15% of the human genome. Changes to these sequences are thought to underlie much of human phenotypic variation and a substantial proportion of genetic causes of disease.
Louisa-Marie Krützfeldt +2 more
doaj +1 more source
Automatic sequences in negative bases and proofs of some conjectures of shevelev
RAIRO - Theoretical Informatics and Applications, 2023 We discuss the use of negative bases in automatic sequences. Recently the theorem-prover Walnut has been extended to allow the use of base (—k) to express variables, thus permitting quantification over ℤ instead of ℕ. This enables us to prove results about two-sided (bi-infinite) automatic sequences. We first explain the theory behind negative bases in
Jeffrey O. Shallit +2 more
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
sequence-toolbox/SeQUeNCe: Parallel Paper
, 2023 <p>This is the SeQUeNCe release code used in preparation of our parallel simulation publication. The corresponding preprint may be found on <a href="https://doi.org/10.48550/arXiv.2111.03918">arXiv</a>.</p ...
Martin Suchara +8 more
core +1 more source
EnergiesCurrent harmonics in six-phase permanent magnet synchronous motors (PMSMs) arise from inherent asymmetries caused by manufacturing tolerances and nonlinear characteristics in the inverter output. Additionally, magnetic saturation and slight imbalances in
Yu-Ting Lin +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Negative avoiding sequences of span $n$ are periodic sequences of elements from $\mathbb{Z}_k$ for some $k$ with the property that no $n$-tuple occurs more than once in a period and if an $n$-tuple does occur then its negative does not. They are a special type of cut-down de Bruijn sequence with potential position-location applications.
Mitchell, Chris J, Wild, Peter R
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Sequences with finitely many negative squares
Journal of Functional Analysis, 1988 Let \({\mathbb{N}}_ 0=\{all\) nonnegative integers\(\}\), \({\mathbb{Z}}=\{all\) integers including zero\(\}\), \({\mathbb{R}}=\{all\) real numbers\(\}\). The following theorems typify the nature of the results of this paper: Theorem. Suppose that the sequence \(f:{\mathbb{N}}_ 0\to {\mathbb{R}}\) has K negative squares and is polynomially determinate.
Berg, C +2 more
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source