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Neurobiological background of negative symptoms [PDF]

European Archives of Psychiatry and Clinical Neuroscience, 2015
Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct. We tried to review the findings published to date investigating neurobiological abnormalities after reducing the heterogeneity of the negative symptoms construct.
GALDERISI, Silvana, MERLOTTI, Eleonora, MUCCI, Armida   +2 more
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Categorizing and assessing negative symptoms [PDF]

Current Opinion in Psychiatry, 2017
To provide a review on studies published in the last year relevant to the categorization and assessment of negative symptoms.Recent research supported the validity of the 'deficit/non-deficit schizophrenia' categorization. Few studies confirmed the validity of the category 'persistent negative symptoms', whereas no recent study explored the validity of
BUCCI, Paola, GALDERISI, Silvana
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Cluster analysis of negative symptoms identifies distinct negative symptom subgroups

Schizophrenia Research, 2022
The heterogeneity of schizophrenia has been acknowledged for decades because of the diverse presentation of symptoms, illness course, and treatment response noted between individuals diagnosed with the disorder. Cluster analysis has been used as a statistical method to determine whether schizophrenia subgroups might be identified based on symptom ...
Nina B, Paul, Gregory P, Strauss, Jessica J, Woodyatt, Michelle G, Paul, Jennifer R, Keene, Daniel N, Allen   +5 more
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Antipsychotic drugs for patients with schizophrenia and predominant or prominent negative symptoms: a systematic review and meta-analysis [PDF]

European Archives of Psychiatry and Clinical Neuroscience, 2018
BACKGROUND Negative symptoms are the core of schizophrenia, but whether antipsychotics are efficacious for their treatment is unclear. Moreover, there is debate whether patients in relevant trials should have predominant negative symptoms or whether ...
Adriani Nikolakopoulou, Yikang Zhu, Johannes Schneider-Thoma   +2 more
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The Concept of Negative Symptoms

British Journal of Psychiatry, 1989
In a recent edition of the Schizophrenia Bulletin devoted to negative symptoms, the editor suggested at the beginning of his preface that what he called the “positive–negative symptom distinction” had been introduced into psychiatry only a decade previously (Levine, 1985).
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The Negative Symptom Challenge

Archives of General Psychiatry, 1992
Fenton and McGlashan 1 note the relatively recent attention to the proposition that deficit or negative symptoms in schizophrenia have a distinct pathophysiologic process from that which underlies the production of positive psychotic symptoms. Although the attention is new, the proposition is not.
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