Results 71 to 80 of about 2,776,258 (309)
Mazindol Treatment of Negative Symptoms [PDF]
Neuropsychopharmacology, 2000 Hypodopaminergic and hyponoradrenergic pathophysiology may be a basis for primary and/or secondary negative symptoms in schizophrenia. The hypothesis that enhanced neurotransmission in these systems would be therapeutic for negative symptoms was tested by comparing mazindol and placebo in a double-blind, cross-over design trial.
W T, Carpenter +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Schizophrenia-negative symptoms
Middle East Current Psychiatry, 2014 Negative symptoms of schizophrenia, account vastly for its functional disability and often persist despite pharmacological treatment. The aim of the study was to detect cases of resistant negative schizophrenia in institutionalized patients, compare between groups of resistant and nonresistant cases, formulate comprehensive criteria for resistant ...
Mamdouh M. Al Gamal +2 more
openaire +1 more source
Role of Self-Worth Contingencies on Sleep Quality Due to Discrimination and Depressive Symptoms [PDF]
, 2020 Role of Self-Worth Contingencies on Sleep Quality Due to Discrimination and Depressive Symptoms Victoria Cambar, Depts. of Psychology and Criminal Justice, Ruth Laryea, and Bianca Owens and Chelsie Dunn, Dept.
Cambar, Victoria +3 more
core +1 more source
Hidden scars in depression? Implicit and explicit self-associations following recurrent depressive episodes [PDF]
, 2013 To help explain the recurrent nature of major depressive disorder, we tested the hypothesis that depressive episodes and/or the duration of depressive symptoms may give rise to persistent dysfunctional implicit and/or more explicit self-associations ...
Bockting, Claudi LH +4 more
core +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
EFFICACY OF RISPERIDONE ON POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA AND MEMORY FUNCTIONS
Psychiatry and Clinical Psychopharmacology, 2021 Objectives: Symptoms due to cognitive impairment are common in patients with schizophrenia. Those are present before the onset of schizophrenia and are persistent during the course.
Yarkın Özcan +3 more
doaj
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source