Results 51 to 60 of about 1,119,337 (334)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Challenges of Deliberation and Participation [PDF]
Les Ateliers de l’Ethique, 2006 The future of sustainability is tied to the future of our ability to manage interconnectedness and interdependence, and thus to our abilities to engage in cooperative, value-creating public deliberations and negotiations.
John Forester
doaj
Judgment and Decision Making, 2010 The paper extends research on fixed-pie perceptions by suggesting that disputants may prefer proposals that are perceived to be equally attractive to both parties (i.e., balanced) rather than one-sided, because balanced agreements are seen as more likely
Deepak Malhotra, Jeremy Ginges
doaj +1 more source
Mediation, arbitration and negotiation [PDF]
, 2007 We compare three common dispute resolution processes { negotiation, mediation, and arbitration { in the framework of Crawford and Sobel (1982). Under negotiation, the two parties engage in (possibly arbitrarily long) face-to-face cheap talk.
Goltsman, M. +3 more
core
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
The potential of generative AI for personalized persuasion at scale
Scientific ReportsMatching the language or content of a message to the psychological profile of its recipient (known as “personalized persuasion”) is widely considered to be one of the most effective messaging strategies.
S. C. Matz +5 more
doaj +1 more source
Ukraine and Canada: The European Union as a Partner in Negotiation
Історико-політичні проблеми сучасного світу, 2020 The European Union as a mode of European Unification is a good example of an international actor channelling negotiation processes in an optimal way. As both Ukraine and Canada will continue and probably intensify negotiation processes with the European
Пол В. Міртс
doaj +1 more source
Train schedule coordination at an interchange station through agent negotiation [PDF]
, 2011 In open railway markets, coordinating train schedules at an interchange station requires negotiation between two independent train operating companies to resolve their operational conflicts.
Ho, Mark, Ip, Kwan Ho, Tsang, Chi Wai
core +3 more sources
Arthritis Care &Research, EarlyView.Objective This study aimed to evaluate the impact of a series of policies that mandated switching patients with inflammatory arthritis (IA) from an originator biologic to a biosimilar in British Columbia, Canada, on health care resource use and cost.
HaoHung Dang +4 more
wiley +1 more source