Results 41 to 50 of about 826,952 (265)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Argentina and Germany: trade and trade policy
Revista de Economía y Estadística, 2005 I will focus my presentation by highlighting and commenting on thefollowing topics: bilateral relations between Argentina, Germany and the EU, the ongoing EU-MERCOSUR negotiations and some other trade related and economic aspects.
Hans Jürgen Froese
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Multifaceted nature of military negotiations
Nowoczesne Systemy ZarządzaniaResearch objectives and hypothesis/research questions The aim of the article is to emphasize the uniqueness and multidimensionality of military negotiations, to indicate potential opportunities in the area of development, to develop a specialized ...
Krzysztof Paweł Kałucki
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UK-Japan Strategic Partnership in Light of Brexit [PDF]
Научно-аналитический вестник Института Европы РАН, 2019 The paper considers the UK policy towards Japan defined as its key ally in Asia. In light of upcoming Brexit, Great Britain tends to intensify the political dialogue with Tokyo in order to demonstrate alliances with «natural partners» all over the world.
Kira Godovanyuk
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FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Culture and Workplace Mediation
Revista de Cultura de Paz, 2017 The analysis of conflict and mediation in the field of organizations is an area of great theoretical and applied interest. In organizations with a high demographic diversity, it is necessary to analyse these processes using a cultural aproach.
Francisco J. Medina +2 more
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FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Legal Security of Parties in the Aspect of Dispute Settlement in the World Trade Organization
Journal of Modern ScienceOne of the basic elements of world order is properly functioning legal systems of individual states. The Sars-Covid pandemic and armed conflicts around the world, including those involving Europe, have strained the certainty of legal transactions in the ...
Wojciech Konaszczuk
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