Results 61 to 70 of about 1,694,129 (281)

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Neighborhood Granule Classifiers

Applied Sciences, 2018
Classifiers are divided into linear and nonlinear classifiers. The linear classifiers are built on a basis of some hyper planes. The nonlinear classifiers are mainly neural networks. In this paper, we propose a novel neighborhood granule classifier based
Hongbo Jiang, Yumin Chen
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Neighborhood conditional mutual information entropy attribute reduction algorithm for hybrid data

大数据, 2022
Attribute reduction is an important research content of the rough set theory.Its main purpose is to eliminate irrelevant attributes in information systems, reduce data dimensions and improve data knowledge discovery performance.However, most of the ...
Haibo LAN
doaj  

Feature selection based on self-information and entropy measures for incomplete neighborhood decision systems

Complex & Intelligent Systems, 2022
For incomplete datasets with mixed numerical and symbolic features, feature selection based on neighborhood multi-granulation rough sets (NMRS) is developing rapidly.
Meng Yuan, Jiucheng Xu, Tao Li, Yuanhao Sun   +3 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Neighborhood Rough Set based Multi-document Summarization

CoRR, 2021
This research paper proposes a novel Neighbourhood Rough Set based approach for supervised Multi-document Text Summarization (MDTS) with analysis and impact on the summarization results for MDTS. Here, Rough Set based LERS algorithm is improved using Neighborhood Rough Set which is itself a novel combination called Neighborhood-LERS to be experimented ...
openaire   +3 more sources

Study on Interval-valued Dual Hesitant Fuzzy β Covering Rough Set Model

Journal of Harbin University of Science and Technology
To effectively handle the problem of decision-making with interval-valued hesitant fuzzy information, this paper proposes four models of interval-valued dual hesitant fuzzy β coverage rough sets,which are combined with interval-valued dual hesitant fuzzy
REN Haowei, WANG Qinghai
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Reduction of Information Systems via Rough Set Model

, 2022
Rough sets are efficient for attribute reduction and in extracting rules in data mining. There are many important problems in rough sets and we use algorithms to solve them. An important idea of rough sets is to approximately represent a whole space with
A. A. Nasef, M. Shokry, Salwa E. Kozaa, A. E. Shalabi   +3 more
core   +1 more source