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It is increasingly being recognised that the interplay between commensal and pathogenic bacteria can dictate the outcome of infection. Consequently, there is a need to understand how commensals interact with their human host and influence pathogen ...
Rafael Custodio+4 more
doaj +2 more sources
Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis [PDF]
We explored the role of commensal Neisseria in the emergence of third-generation cephalosporin-resistant N. meningitidis. Cefotaxime resistance–conferring penA795 was prevalent among commensal Neisseria isolates in Shanghai, China, and was acquired by a
Youxing Shao+7 more
doaj +2 more sources
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hazel En En Wong+4 more
doaj +4 more sources
An Overview of Neisseria meningitidis
Neisseria meningitidis (the meningococcus) is a member of the normal nasopharyngeal microbiome in healthy individuals, but can cause septicemia and meningitis in susceptible individuals. In this chapter we provide an overview of the disease caused by N. meningitidis and the schemes used to type the meningococcus. We also review the adhesions, virulence
Hollingshead, S, Tang, C
openaire +4 more sources
Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant. [PDF]
Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis.
Barbara Bottazzi+14 more
doaj +2 more sources
Metabolism and virulence in Neisseria meningitidis [PDF]
A longstanding question in infection biology addresses the genetic basis for invasive behavior in commensal pathogens. A prime example for such a pathogen is Neisseria meningitidis. On the one hand it is a harmless commensal bacterium exquisitely adapted to humans, and on the other hand it sometimes behaves like a ferocious pathogen causing potentially
Schoen, Christoph+3 more
openaire +5 more sources
The comparative population genetics of Neisseria meningitidis and Neisseria gonorrhoeae [PDF]
Neisseria meningitidis and N. gonorrhoeae are closely related pathogenic bacteria. To compare their population genetics, we compiled a dataset of 1,145 genes found across 20 N. meningitidis and 15 N. gonorrhoeae genomes. We find that N.
Eyre-Walker, Adam, Vigué, Lucile
core +2 more sources
Neisseria meningitidis: pathogenesis and immunity
The recent advances in cellular microbiology, genomics, and immunology has opened new horizons in the understanding of meningococcal pathogenesis and in the definition of new prophylactic intervention. It is now clear that Neissera meningitidis has evolved a number of surface structures to mediate interaction with host cells and a number of mechanisms ...
Pizza, Mariagrazia, Rappuoli, Rino
openaire +5 more sources
Outbreak of Sexually Transmitted Nongroupable Neisseria meningitidis–Associated Urethritis, Vietnam [PDF]
We report on an outbreak of nongroupable Neisseria meningitidis–associated urethritis, primarily among men who have sex with men in southern Vietnam. Nearly 50% of N. meningitidis isolates were resistant to ciprofloxacin.
Hao Trong Nguyen+17 more
doaj +2 more sources
Rifampin-resistant Neisseria meningitidis
To the Editor: Immediate management of meningococcal disease requires antimicrobial drug treatment of patients with β-lactams and chemoprophylaxis of contact persons with rifampin. High-level resistance to rifampin (MIC >32 mg/L) in Neisseria meningitidis is provoked by mutations (most frequently at the residue His 552) in the rpoB gene encoding the b ...
Muhamed-Kheir Taha+4 more
doaj +4 more sources